Caspase mediated cleavage produces a constitutively active kinase that induces apoptosis (Ghayur et al.,1996).
Ghayur, T, Hugunin, M, Talanian, RV, Ratnofsky, S, Quinlan, C, Emoto, Y, Pandey, P, Datta, R, Huang, Y, Kharbanda, S, Allen, H, Kamen, R, Wong, W, Kufe, D
© 2021 Reactome