Caspase 3-mediated cleavage of PKC delta

Stable Identifier
R-HSA-212552
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Caspase 3-mediated cleavage of PKC delta
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Caspase mediated cleavage produces a constitutively active kinase that induces apoptosis (Ghayur et al.,1996).

Literature References
PubMed ID Title Journal Year
8976194 Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis

Ghayur, T, Hugunin, M, Talanian, RV, Ratnofsky, S, Quinlan, C, Emoto, Y, Pandey, P, Datta, R, Huang, Y, Kharbanda, S, Allen, H, Kamen, R, Wong, W, Kufe, D

J Exp Med 1996
Participants
Input
Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase 3-mediated cleavage of PKC delta (Caenorhabditis elegans)
Caspase 3-mediated cleavage of PKC delta (Canis familiaris)
Caspase 3-mediated cleavage of PKC delta (Danio rerio)
Caspase 3-mediated cleavage of PKC delta (Drosophila melanogaster)
Caspase 3-mediated cleavage of PKC delta (Gallus gallus)
Caspase 3-mediated cleavage of PKC delta (Mus musculus)
Caspase 3-mediated cleavage of PKC delta (Rattus norvegicus)
Caspase 3-mediated cleavage of PKC delta (Sus scrofa)
Authored
Schulze-Osthoff, K  (2007-09-03)
Reviewed
Ranganathan, S  (2007-11-23)
Created
Matthews, L  (2008-02-12)
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