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SERPINH1 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-2127480
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Serpin H1, SERPH_HUMAN
Locations in the PathwayBrowser for interactor IntAct:EBI-25833683 CCSB
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Collagen biosynthesis and modifying enzymes (Homo sapiens)
Procollagen triple helix formation (Homo sapiens)
SERPINH1 [endoplasmic reticulum lumen] (Homo sapiens)
Secretion of collagens (Homo sapiens)
SERPINH1 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50454 SERPINH1
Gene Names
SERPINH1, CBP1, CBP2, HSP47, SERPINH2, PIG14
Chain
signal peptide:1-18, chain:19-418
Reference Genes
BioGPS Gene:871 SERPINH1
COSMIC (genes):SERPINH1 SERPINH1
CTD Gene:871 SERPINH1
dbSNP Gene:871 SERPINH1
ENSEMBL:ENSG00000149257 SERPINH1
HGNC:1546 SERPINH1
Monarch:871 SERPINH1
NCBI Gene:871 SERPINH1
OMIM:600943 SERPINH1
UCSC:P50454 SERPINH1
Reference Transcript
RefSeq:NM_001207014.1 SERPINH1
RefSeq:XM_011545327.1 SERPINH1
RefSeq:NM_001235.3 SERPINH1
Other Identifiers
11744209_s_at
11746320_x_at
11746321_s_at
16729128
207714_3p_s_at
207714_PM_s_at
207714_s_at
3167377
3340591
3340592
3340593
3340594
3340595
3340597
3340598
3340599
3340600
3340601
3340602
3340603
3340604
3340605
3340606
3340607
3340608
3340609
3340610
3340611
3340612
3340613
3340614
3340616
39166_s_at
39167_r_at
7942596
871
A_14_P122803
A_14_P201809
A_23_P76006
A_33_P3269203
D83174_s_at
GE57328
GE59869
GO:0003433
GO:0003723
GO:0004867
GO:0005515
GO:0005518
GO:0005615
GO:0005737
GO:0005783
GO:0005788
GO:0005793
GO:0006986
GO:0030198
GO:0030199
GO:0030312
GO:0031012
GO:0032964
GO:0043226
GO:0045121
GO:0048856
GO:0051082
GO:0051604
GO:0062023
GO:0098772
HMNXSV003012287
ILMN_1751028
PH_hs_0012962
PH_hs_0032271
TC11000809.hg
TC11002788.hg
Participates
as an output of
Secretion of collagens (Homo sapiens)
as a component of
Collagens and tropocollagens:Serpin H1 [endoplasmic reticulum lumen] (Homo sapiens)
Collagen and procollagen triple helices:Serpin H1 [endoplasmic reticulum lumen] (Homo sapiens)
as an input of
Procollagen triple helix formation (Homo sapiens)
Inferred To
Spn77Bb [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn28Dc [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Ghost homologue of SERPINH1 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Ghost homologue of SERPINH1 [endoplasmic reticulum lumen]
(Dictyostelium discoideum)
Ghost homologue of SERPINH1 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
SERPINH1 [endoplasmic reticulum lumen]
(Bos taurus)
SERPINH1 [endoplasmic reticulum lumen]
(Canis familiaris)
SERPINH1 [endoplasmic reticulum lumen]
(Gallus gallus)
SERPINH1 [endoplasmic reticulum lumen]
(Sus scrofa)
Spn77Bc [endoplasmic reticulum lumen]
(Drosophila melanogaster)
serpinh1b [endoplasmic reticulum lumen]
(Danio rerio)
Serpinh1 [endoplasmic reticulum lumen]
(Mus musculus)
Serpinh1 [endoplasmic reticulum lumen]
(Rattus norvegicus)
Spn77Ba [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Homologues of SERPINH1 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Cross References
OpenTargets
ENSG00000149257
ENSEMBL
ENST00000358171
,
ENSP00000350894
,
ENSP00000434412
,
ENST00000524558
,
ENSP00000434657
,
ENST00000533603
HPA
ENSG00000149257-SERPINH1
ZINC - Substances
SERPH_HUMAN
ZINC target
P50454
PRO
P50454
Pharos - Targets
P50454
GlyGen
P50454
Orphanet
SERPINH1
ZINC - Predictions - Purchasable
SERPH_HUMAN
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.706
23
UniProt:Q13200 PSMD2
5
PSMD2 [cytosol]
(R-HSA-68796)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
0.61
4
ChEBI:28304 HEPARIN
0.564
3
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.556
3
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
3
UniProt:P21246 PTN
1
PTN [extracellular region]
(R-HSA-201500)
0.556
3
UniProt:Q9NPC7 MYNN
0.556
3
UniProt:Q6NTF9-3 Q6NTF93
0.556
3
IntAct:EBI-25833683 CCSB
0.556
3
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.556
3
UniProt:Q8TBJ4 PLPPR1
1
LPPR1 [plasma membrane]
(R-HSA-6797625)
0.556
3
UniProt:Q13702-2 Q137022
0.556
3
IntAct:EBI-25836632 CCSB
0.556
3
UniProt:P49184 DNASE1L1
2
DNASE1L1 [extracellular region]
(R-HSA-6806320)
DNASE1L1 [specific granule lumen]
(R-HSA-6799554)
0.556
3
UniProt:Q7Z614-3 SNX20
0.556
3
UniProt:P12830 CDH1
8
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
0.556
3
UniProt:Q9NUD9 PIGV
1
PIGV [endoplasmic reticulum membrane]
(R-HSA-162739)
0.556
3
UniProt:Q99720-4 SIGMAR1
0.556
3
UniProt:Q16586 SGCA
3
SGCA [endoplasmic reticulum membrane]
(R-HSA-9913191)
SGCA [Golgi membrane]
(R-HSA-9913182)
SGCA [plasma membrane]
(R-HSA-9630720)
0.556
3
UniProt:P06756 ITGAV
3
ITGAV(31-1048) [plasma membrane]
(R-HSA-210013)
ITGAV(31-1048) [specific granule membrane]
(R-HSA-6806145)
ITGAV(31-1048) [phagocytic vesicle]
(R-HSA-1236773)
0.556
3
UniProt:Q16549 PCSK7
0.556
3
UniProt:P54253 ATX1
0.556
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:Q8NC51 SERB1
0.556
3
UniProt:Q9NP61 ARFGAP3
1
ARFGAP3 [cytosol]
(R-HSA-6807740)
0.556
3
UniProt:P23276 KEL
1
KEL [plasma membrane]
(R-HSA-5694121)
0.556
3
UniProt:Q8TBE0 BAHD1
0.556
3
UniProt:Q6PI98 INO80C
1
INO80C [nucleoplasm]
(R-HSA-5689605)
0.556
3
UniProt:O75874 IDH1
10
IDH1 [cytosol]
(R-HSA-389549)
IDH1 [peroxisomal matrix]
(R-HSA-389546)
IDH1 [secretory granule lumen]
(R-HSA-6800980)
IDH1 [extracellular region]
(R-HSA-6806433)
IDH1 [tertiary granule lumen]
(R-HSA-6800163)
IDH1 [ficolin-1-rich granule lumen]
(R-HSA-6800977)
IDH1 R132C mutant [cytosol]
(R-HSA-880031)
IDH1 R132S mutant [cytosol]
(R-HSA-880048)
IDH1 R132L mutant [cytosol]
(R-HSA-880000)
IDH1 R132H mutant [cytosol]
(R-HSA-880015)
0.556
3
UniProt:Q8NCS7 SLC44A5
1
SLC44A5 [plasma membrane]
(R-HSA-444459)
0.556
3
UniProt:P54819 AK2
1
AK2 [mitochondrial intermembrane space]
(R-HSA-57822)
0.556
3
UniProt:Q969W3 VCF1
0.556
3
UniProt:O60259 KLK8
3
proKLK8 [extracellular region]
(R-HSA-8850832)
KLK8 [extracellular region]
(R-HSA-8850833)
KLK8 propeptide [extracellular region]
(R-HSA-8850829)
0.556
3
UniProt:Q16560-2 SNRNP35
0.556
3
UniProt:P61513 RPL37A
1
RPL37A [cytosol]
(R-HSA-72468)
0.556
3
UniProt:P15036 ETS2
2
ETS2 [nucleoplasm]
(R-HSA-1629811)
p-T72-ETS2 [nucleoplasm]
(R-HSA-3132735)
0.556
3
UniProt:Q8NE08 Q8NE08
0.556
3
UniProt:P0DTC3 3a
9
O-glycosyl 3a [virion membrane]
(R-COV-9694395)
O-glycosyl 3a [endocytic vesicle membrane]
(R-COV-9694729)
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694386)
GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694658)
3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694716)
3a [endoplasmic reticulum lumen]
(R-COV-9694584)
O-glycosyl 3a [endolysosome membrane]
(R-COV-9754541)
O-glycosyl 3a [plasma membrane]
(R-COV-9694433)
O-glycosyl 3a [extracellular region]
(R-COV-9694387)
0.547
2
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.527
3
UniProt:P02452 COL1A1
20
3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023648)
3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023667)
GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023604)
GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022999)
3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023559)
3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023582)
COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1650777)
3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985659)
3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022446)
3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022951)
3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022954)
5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985663)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396137)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396440)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396471)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396464)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396068)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396388)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396315)
Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396441)
0.499
2
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