Elastin cross-linking by lysyl oxidase

Stable Identifier
R-HSA-2129375
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Soluble monomers of tropoelastin are cross-linked by the oxidative deamination of lysine residues, catalyzed by lysyl oxidase (LOX). The first step in the cross linking reaction is the oxidative formation of the delta-aldehyde, known as alpha aminoadipic semialdehyde or allysine (Partridge 1963). Subsequent spontaneous reactions lead to the formation of cross-links through dehydrolysinonorleucine and allysine aldol, a trifunctional cross-link dehydromerodesmosine and two tetrafunctional cross-links desmosine and isodesmosine (Lucero & Kagan 2006), which are unique to elastin.

Literature References
PubMed ID Title Journal Year
6123066 Lysyl oxidase: preparation and role in elastin biosynthesis

Kagan, HM, Sullivan, KA

Methods Enzymol 1982
16906757 Tropoelastin massively associates during coacervation to form quantized protein spheres

Clarke, AW, Arnspang, EC, Mithieux, SM, Korkmaz, E, Braet, F, Weiss, AS

Biochemistry 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein-lysine 6-oxidase activity of Lysyl oxidases:Cu2+ [extracellular region]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created