Dimerization of DAP12

Stable Identifier
R-HSA-2130151
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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DAP12 is expressed as a disulfide-bonded homodimer on NK cells, myeloid cells and a subset of T cells. Cystine-7 in the extracellular domain is involved in the interchain disulphide bond (numbering according to Lanier et al. 1998).

Literature References
PubMed ID Title Journal Year
20890284 The structural basis for intramembrane assembly of an activating immunoreceptor complex

Call, ME, Wucherpfennig, KW, Chou, JJ

Nat Immunol 2010
9490415 Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

Lanier, LL, Corliss, BC, Wu, J, Leong, C, Phillips, JH

Nature 1998
16623599 The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site

Feng, J, Call, ME, Wucherpfennig, KW

PLoS Biol 2006
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