ABL phosphorylates WAVEs

Stable Identifier
R-HSA-2130194
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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ABL phosphorylates WAVEs
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Abelson interactor-1 (ABL) tyrosine kinase phosphorylates the strictly conserved tyrosine 150 in WAVE2 (Y151 in WAVE1 and WAVE3) (Leng et al. 2003, Chen et al. 2010).
Literature References
PubMed ID Title Journal Year
15657136 Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation

Cheung, P, Zhang, J, Badour, K, Siu, M, Leng, Y, Arpaia, E, Siminovitch, K, Freeman, S

Proc Natl Acad Sci U S A 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of ABL1 [cytosol]

Physical Entity
ABL1 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
ABL phosphorylates WAVEs (Bos taurus)
ABL phosphorylates WAVEs (Caenorhabditis elegans)
ABL phosphorylates WAVEs (Canis familiaris)
ABL phosphorylates WAVEs (Drosophila melanogaster)
ABL phosphorylates WAVEs (Gallus gallus)
ABL phosphorylates WAVEs (Mus musculus)
ABL phosphorylates WAVEs (Rattus norvegicus)
ABL phosphorylates WAVEs (Sus scrofa)
ABL phosphorylates WAVEs (Xenopus tropicalis)
Authored
Jupe, S  (2009-09-02)
Reviewed
Rosales, C  (2012-05-15)
Rivero Crespo, F  (2014-12-26)
Created
Garapati, P V  (2012-02-21)
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