Reactome | CLEC7A [plasma membrane]

CLEC7A [plasma membrane]

Stable Identifier

R-HSA-2130683

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Dectin-1, C-type lectin domain family 7 member A

Locations in the PathwayBrowser for interactor UniProt:Q8N205 SYNE4

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External Reference Information

External Reference

UniProt:Q9BXN2 CLEC7A

Gene Names

CLEC7A, BGR, CLECSF12, DECTIN1, UNQ539/PRO1082

Chain

chain:1-247

Reference Genes

BioGPS Gene:64581 CLEC7A

COSMIC (genes):CLEC7A CLEC7A

CTD Gene:64581 CLEC7A

dbSNP Gene:64581 CLEC7A

ENSEMBL:ENSG00000172243 CLEC7A

HGNC:14558 CLEC7A

KEGG:hsa:64581 CLEC7A

Monarch:64581 CLEC7A

NCBI Gene:64581 CLEC7A

OMIM:606264 CLEC7A

UCSC:Q9BXN2 CLEC7A

Reference Transcript

Participates

as an input of

CLEC7A binds 1,3-beta-D-glucan (Homo sapiens)

as a component of

CLEC7A:1,3-beta-D-glucan [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y15-CLEC7A [plasma membrane]

Inferred To

CLEC7A [plasma membrane] (Bos taurus)

CLEC7A [plasma membrane] (Canis familiaris)

CLEC7A [plasma membrane] (Sus scrofa)

Clec7a [plasma membrane] (Mus musculus)

Clec7a [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_047285315.1, XP_054228878.1, XP_054228879.1, XP_006719198.1, NP_922945.1, NP_922939.1, NP_072092.2, NP_922938.1, NP_922941.1, NP_922940.1

Guide to Pharmacology - Targets

2927

OpenTargets

ENSG00000172243

ENSEMBL

ENST00000310002, ENSP00000344723, ENST00000465100, ENST00000353231, ENST00000298523, ENSP00000432876, ENSP00000302569, ENSG00000172243, ENST00000304084, ENSP00000379743, ENSP00000312089, ENST00000349926, ENSP00000298523, ENST00000533022, ENSP00000266456, ENSP00000436923, ENST00000531192, ENST00000529761, ENST00000396484, ENSP00000434392, ENSP00000431461

GeneCards

CLEC7A

HPA

ENSG00000172243-CLEC7A

PRO

Q9BXN2

Pharos - Targets

Q9BXN2

Orphanet

CLEC7A

HMDB Protein

HMDBP12648

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60238 BNIP3L	1	BNIP3L [mitochondrial outer membrane] (R-HSA-6798001)	0.666	6
UniProt:Q9BSE2 TMM79			0.666	4
UniProt:Q8N205 SYNE4			0.666	7
UniProt:Q9NZG7 NINJ2			0.556	3
UniProt:Q12983 BNIP3			0.556	3
UniProt:Q16625 OCLN	4	OCLN [plasma membrane] (R-HSA-351846) OCLN(321-522) [plasma membrane] (R-HSA-351873) OCLN(1-320) [plasma membrane] (R-HSA-351854) OCLN [cell junction] (R-HSA-2160944)	0.556	3
UniProt:Q9BZL3 SMIM3			0.556	3
UniProt:Q9BRL5 Q9BRL5			0.556	3
UniProt:Q86UP2 KTN1	4	KTN1 [endoplasmic reticulum lumen] (R-HSA-8956694) p-KTN1 [endoplasmic reticulum lumen] (R-HSA-8956968) KTN1 [endoplasmic reticulum membrane] (R-HSA-201604) KTN1 [plasma membrane] (R-HSA-9696518)	0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q9BZ11-2 ADAM33			0.556	3
UniProt:Q9BU27 Q9BU27			0.556	3
UniProt:P53801 PTTG			0.556	3
UniProt:Q01638 IL1RL1	1	IL1RL1 [plasma membrane] (R-HSA-197594)	0.556	3
UniProt:Q9NRS4-3 TMPRSS4			0.556	3

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