Reactome | PARD6A [cell junction]

PARD6A [cell junction]

Stable Identifier

R-HSA-2134480

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cell junction

Synonyms

Partitioning defective 6 homolog alpha, PAR6A_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
      - TGFBR1 is recruited to tight junctions by PARD6A (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD6A [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD6A [cell junction] (Homo sapiens)
      - TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD6A [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD6A [cell junction] (Homo sapiens)
      - TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD6A [cell junction] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NPB6 PARD6A

Gene Names

PARD6A, PAR6A

Chain

chain:1-346

Reference Genes

BioGPS Gene:50855 PARD6A

COSMIC (genes):PARD6A PARD6A

CTD Gene:50855 PARD6A

dbSNP Gene:50855 PARD6A

ENSEMBL:ENSG00000102981 PARD6A

HGNC:15943 PARD6A

KEGG:hsa:50855 PARD6A

Monarch:50855 PARD6A

NCBI Gene:50855 PARD6A

OMIM:607484 PARD6A

UCSC:Q9NPB6 PARD6A

Reference Transcript

Participates

as a component of

PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)

Other forms of this molecule

PARD6A [plasma membrane]

PARD6A [cytosol]

p-S345-PARD6A [plasma membrane]

Cross References

RefSeq

NP_058644.1, NP_001032358.1

ENSEMBL

ENST00000219255, ENSP00000219255, ENSG00000102981, ENST00000458121, ENSP00000392388

OpenTargets

ENSG00000102981

GeneCards

PARD6A

HPA

ENSG00000102981-PARD6A

PRO

Q9NPB6

Pharos - Targets

Q9NPB6

HMDB Protein

HMDBP08500

PDB

1WMH

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.949	17
UniProt:Q05513 PRKCZ	5	PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.906	10
UniProt:P60953 CDC42	3	CDC42 [plasma membrane] (R-HSA-449545) CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.755	7
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802)	0.508	2