Synthesis of Hepoxilins (HX) and Trioxilins (TrX)

Stable Identifier
R-HSA-2142696
Type
Pathway
Species
Homo sapiens
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Hepoxilins are biologically relevant signalling molecules produced by certain arachidonate 12-lipoxygenase (ALOX12s). Hepoxilin A3 (HXA3) and B3 (HXB3) have been identified, both of which incorporate an epoxide across the C-11 and C-12 double bond, as well as an additional hydroxyl moiety. HXA3 has a C-8 hydroxyl, whereas the HXB3 hydroxyl occurs at C-10. The epoxy moiety is labile and can be hydrolyzed either by a hepoxilin specific epoxide hydrolase (HXEH) or in acidic aqueous solution to form the corresponding diol metabolites trioxilin A3 (TrXA3) and B3 (TrXB3) (Buczynski et al. 2009, Vance & Vance 2008).

Literature References
PubMed ID Title Journal Year
19244215 Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology

Buczynski, MW, Dumlao, DS, Dennis, EA

J Lipid Res 2009
  Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition

Vance, DE, Vance, JE

  2008
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