Reactome | Transcriptional activation of mitochondrial biogenesis

Transcriptional activation of mitochondrial biogenesis

Stable Identifier

R-HSA-2151201

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, nucleoplasm, mitochondrial matrix

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Transcriptional activation of mitochondrial biogenesis

Click the image above or here to open this pathway in the Pathway Browser

Phosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate the transcription of nuclear-encoded, mitochondrially targeted proteins such as TFB2M, TFB1M, and TFAM. PGC-1beta and PPRC appear to act similarly to PGC-1alpha but have not been as well studied. Transcription of PPARGC1A itself is upregulated by CREB1 (in response to calcium), MEF2C/D, ATF2, and PPARGC1A. Transcription of PPARGC1A is repressed by NR1D1 (REV-ERBA).

Literature References

PubMed ID	Title	Journal	Year
19575678	Transcriptional control of mitochondrial biogenesis and function Kralli, A, Hock, MB	Annu Rev Physiol	2009
22265687	Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes Suliman, HB, Piantadosi, CA	Biochim. Biophys. Acta	2012
19682549	Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging Saleem, A, Joseph, AM, Nguyen, LM, Collu-Marchese, M, Ljubicic, V, Uguccioni, G, Hood, DA, Lai, RY	Biochim Biophys Acta	2010
20933024	Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network Scarpulla, RC	Biochim Biophys Acta	2011
22817841	Transcriptional integration of mitochondrial biogenesis Scarpulla, RC, Kelly, DP, Vega, RB	Trends Endocrinol. Metab.	2012