Reactome | FBN1(28-2731) [extracellular region]

FBN1(28-2731) [extracellular region]

Stable Identifier

R-HSA-2159853

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Fibrillin-1 peptide, FBN1_HUMAN, FBN1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P35555 FBN1

Gene Names

FBN1, FBN

Chain

signal peptide:1-24, propeptide:25-44, chain:45-2731, chain:2732-2871

Reference Genes

BioGPS Gene:2200 FBN1

COSMIC (genes):FBN1 FBN1

CTD Gene:2200 FBN1

dbSNP Gene:2200 FBN1

ENSEMBL:ENSG00000166147 FBN1

HGNC:3603 FBN1

KEGG Gene (Homo sapiens):2200 FBN1

Monarch:2200 FBN1

NCBI Gene:2200 FBN1

OMIM:134797 FBN1

UCSC:P35555 FBN1

Reference Transcript

RefSeq:NM_000138.4 FBN1

Other Identifiers

0001050181

11720507_at

11720508_at

11720509_a_at

11754368_a_at

11758093_s_at

16808793

202765_s_at

202766_s_at

2200

235318_at

32535_at

3623030

3623032

3623033

3623034

3623035

3623036

3623037

3623038

3623043

3623045

3623047

3623052

3623054

3623056

3623058

3623059

3623061

3623062

3623063

3623064

3623066

3623067

3623068

3623069

3623070

3623071

3623072

3623074

3623076

3623077

3623078

3623080

3623081

3623082

3623083

3623085

3623087

3623088

3623089

3623092

3623094

3623095

3623096

3623097

3623098

3623099

3623100

3623102

3623103

3623104

3623105

3623106

3623107

3623109

3623111

3623114

3623117

3623118

3623122

3623123

3623125

3623126

3623127

3623128

3623136

3623139

3623160

3623162

3623164

3623165

3623179

3623180

63635_at

7988467

A_33_P3348239

GE59892

GE856895

GO:0001501

GO:0001527

GO:0001656

GO:0001822

GO:0002376

GO:0003674

GO:0005178

GO:0005179

GO:0005198

GO:0005201

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005604

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0006464

GO:0007155

GO:0007165

GO:0007507

GO:0008150

GO:0008201

GO:0009058

GO:0009653

GO:0009790

GO:0030023

GO:0030154

GO:0030198

GO:0031012

GO:0033627

GO:0034641

GO:0035582

GO:0035583

GO:0042802

GO:0043010

GO:0043167

GO:0043226

GO:0043687

GO:0044267

GO:0044877

GO:0045671

GO:0048048

GO:0048050

GO:0048856

GO:0062023

GO:0071560

GO:1990314

GO:2001205

Hs.23850.0.A1_3p_at

Hs.750.0.S1_3p_a_at

ILMN_1783182

L13923_at

PH_hs_0000086

TC15001335.hg

g4557590_3p_a_at

Participant Of

hasMember

Fibrillin peptides [extracellular region]

repeatedUnit

Fibrillin-1 [extracellular region]

Other forms of this molecule

FBN1 [extracellular region]

FBN1 [endoplasmic reticulum lumen]

p-FBN1 [endoplasmic reticulum lumen]

FBN1(28-?) [extracellular region]

FBN1(1-2731) [extracellular region]

FBN1(2732-2871) [extracellular region]

Inferred To

FBN1(28-2731) [extracellular region] (Dictyostelium discoideum)

FBN1 [extracellular region] (Canis familiaris)

FBN1 [extracellular region] (Gallus gallus)

fbn2b [extracellular region] (Danio rerio)

Fbn1 [extracellular region] (Mus musculus)

Fbn1 [extracellular region] (Rattus norvegicus)

fbn1 [extracellular region] (Xenopus tropicalis)

Homologues of FBN1(28-2731) [extracellular region] (Dictyostelium discoideum)

Cross References

RefSeq

NP_000129.3

OpenTargets

ENSG00000166147

GeneCards

P35555

HPA

ENSG00000166147-FBN1

Ensembl

ENSG00000166147, ENSP00000325527, ENST00000316623

PRO

P35555

Orphanet

16032

HMDB Protein

HMDBP07679

PDB

1APJ, 5MS9, 2W86, 1UZJ, 1EMN, 1EMO, 1UZQ, 2M74, 1LMJ, 1UZK, 1UZP

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35555 FBN1	7	FBN1 [endoplasmic reticulum lumen] (R-HSA-8956726) FBN1 [extracellular region] (R-HSA-265402) p-FBN1 [endoplasmic reticulum lumen] (R-HSA-8956900) FBN1(28-2731) [extracellular region] (R-HSA-2159853) FBN1(28-?) [extracellular region] (R-HSA-2514785) FBN1(1-2731) [extracellular region] (R-HSA-2514817) FBN1(2732-2871) [extracellular region] (R-HSA-2159838)	0.799	6
UniProt:O95967 EFEMP2	1	EFEMP2 [extracellular region] (R-HSA-2161231)	0.611	3
UniProt:Q7L5D6 GET4	1	GET4 [cytosol] (R-HSA-9609918)	0.556	3
UniProt:O14964 HGS	2	HGS [phagocytic vesicle lumen] (R-HSA-9635660) HGS [cytosol] (R-HSA-182954)	0.556	3
UniProt:Q96EQ0 SGTB			0.556	3
UniProt:P28300 LOX	3	LOX(22-417) [extracellular region] (R-HSA-2022071) LOX(22-168) [extracellular region] (R-HSA-2022074) LOX [extracellular region] (R-HSA-2022085)	0.544	2
UniProt:P15502 ELN	3	ELN(?-786) [extracellular region] (R-HSA-2514775) ELN(27-?) [extracellular region] (R-HSA-2514783) ELN [extracellular region] (R-HSA-1454880)	0.524	3
UniProt:P55083 MFAP4	1	MFAP4 [extracellular region] (R-HSA-2161384)	0.488	2

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