Collagen type I binds integrin alpha11beta1

Stable Identifier
R-HSA-216045
Type
Reaction [binding]
Species
Homo sapiens
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The integrin alpha11beta1 along with alpha1beta1, alpha2beta1 and alpha10beta1 are referred to as a collagen receptor subgroup of the integrin family. Integrin alpha11beta1 binds preferentially to the fibril-forming collagen types I and II, binding to type III is weaker and collagens IV and VI are poor ligands (Zhang et al. 2003).

Literature References
PubMed ID Title Journal Year
12496264 alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens

Zhang, WM, Kapyla, J, Puranen, JS, Knight, CG, Tiger, CF, Pentikainen, OT, Johnson, MS, Farndale, RW, Heino, J, Gullberg, D

J Biol Chem 2003
11518510 alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells

Tiger, CF, Fougerousse, F, Grundstrom, G, Velling, T, Gullberg, D

Dev Biol 2001
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