Reactome | Interaction of integrin alphaDbeta2 with fibrin

Interaction of integrin alphaDbeta2 with fibrin

Stable Identifier

R-HSA-216069

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Interaction of integrin alphaDbeta2 with fibrin

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Integrin alphaDbeta2 is a member of the beta2 family. It is expressed poorly on peripheral blood leukocytes but strongly on macrophages. alphaDbeta2 has the ability to interact with multiple ligands, including many ECM proteins. The interaction of beta2 integrins with ligands is mediated by their I-domains of the alpha subunits. The alphaD I-domain mediates the interaction with the ECM protein fibrinogen.

Literature References

PubMed ID	Title	Journal	Year
10438935	The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1 Van der Vieren, M, Crowe, DT, Hoekstra, D, Vazeux, R, Hoffman, PA, Grayson, MH, Bochner, BS, Gallatin, WM, Staunton, DE	J Immunol	1999
16239428	Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties Yakubenko, VP, Yadav, SP, Ugarova, TP	Blood	2006