Reactome | Interaction of integrin alphaIIbbeta3 with von Willebrand factor

Interaction of integrin alphaIIbbeta3 with von Willebrand factor

Stable Identifier

R-HSA-216072

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Interaction of integrin alphaIIbbeta3 with von Willebrand factor

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Integrin alphaIIbbeta3 (glycoprotein IIb-IIIa, GP IIb-IIIa) is one of the major platelet receptor that is involved in aggregation and adhesion of platelets. In resting stage alphaIIbbeta3 is inactive and does not interact with its ligands but upon activation or vascular injury it binds to the ECM protein von Willebrand factor (vWf) and stimulate the platelet aggregation.

Literature References

PubMed ID	Title	Journal	Year
12585966	Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C Giuliano, S, Jackson, SP, Rooney, M, Nesbitt, WS	Biochem J	2003
11713259	Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow Harper, IS, Yap, CL, Goncalves, I, Giuliano, S, Kulkarni, S, Jackson, SP, Nesbitt, WS, Salem, HH, Dopheide, SM	J Biol Chem	2002