Interaction of integrin alphaIIbbeta3 with von Willebrand factor

Stable Identifier
R-HSA-216072
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Integrin alphaIIbbeta3 (glycoprotein IIb-IIIa, GP IIb-IIIa) is one of the major platelet receptor that is involved in aggregation and adhesion of platelets. In resting stage alphaIIbbeta3 is inactive and does not interact with its ligands but upon activation or vascular injury it binds to the ECM protein von Willebrand factor (vWf) and stimulate the platelet aggregation.

Literature References
PubMed ID Title Journal Year
11713259 Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow

Nesbitt, WS, Kulkarni, S, Giuliano, S, Goncalves, I, Dopheide, SM, Yap, CL, Harper, IS, Salem, HH, Jackson, SP

J Biol Chem 2002
12585966 Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C

Giuliano, S, Nesbitt, WS, Rooney, M, Jackson, SP

Biochem J 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created