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MDK [extracellular region]
Stable Identifier
R-HSA-2160953
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Midkine, MK1
Locations in the PathwayBrowser for interactor UniProt:Q9UQ35 SRRM2
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
MDK and PTN in ALK signaling (Homo sapiens)
ALK binds ligand midkine (MDK) (Homo sapiens)
MDK [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21741 MDK
Gene Names
MDK, MK1, NEGF2
Chain
signal peptide:1-20, chain:21-143
Reference Genes
BioGPS Gene:4192 MDK
COSMIC (genes):MDK MDK
CTD Gene:4192 MDK
dbSNP Gene:4192 MDK
ENSEMBL:ENSG00000110492 MDK
HGNC:6972 MDK
KEGG:hsa:4192 MDK
Monarch:4192 MDK
NCBI Gene:4192 MDK
OMIM:162096 MDK
UCSC:P21741 MDK
Reference Transcript
RefSeq:NM_002391.4 MDK
RefSeq:NM_001270552.1 MDK
RefSeq:NM_001270550.1 MDK
RefSeq:XM_011520116.2 MDK
RefSeq:NM_001270551.1 MDK
RefSeq:XM_017017764.1 MDK
RefSeq:NM_001012333.2 MDK
RefSeq:NM_001012334.2 MDK
Other Identifiers
11718037_x_at
11731346_a_at
11744457_x_at
11744803_x_at
11746952_x_at
11755105_a_at
16724346
209035_PM_at
209035_at
3329342
3329344
3329345
3329346
3329348
3329349
3329350
3329351
3329352
3329353
3329354
3329355
3329356
3329357
3329358
3329359
38003_s_at
38124_at
4192
52964_at
577_at
75242_f_at
7939665
A_14_P136277
A_23_P116235
A_33_P3239338
GE79315
GE86483
GO:0001662
GO:0002232
GO:0002286
GO:0002376
GO:0002690
GO:0005515
GO:0005576
GO:0006355
GO:0007010
GO:0007162
GO:0007165
GO:0007399
GO:0007614
GO:0008083
GO:0008201
GO:0009611
GO:0010667
GO:0010718
GO:0010759
GO:0010838
GO:0010976
GO:0010996
GO:0021542
GO:0021681
GO:0021766
GO:0021987
GO:0022414
GO:0022600
GO:0030154
GO:0030279
GO:0030312
GO:0030325
GO:0030335
GO:0030421
GO:0031012
GO:0032330
GO:0032735
GO:0035374
GO:0035556
GO:0042246
GO:0043524
GO:0044849
GO:0045582
GO:0045590
GO:0045785
GO:0045893
GO:0046850
GO:0048018
GO:0048477
GO:0048714
GO:0048856
GO:0048870
GO:0050729
GO:0050795
GO:0050877
GO:0051781
GO:0061036
GO:0062023
GO:0071673
GO:0090023
GO:0090090
GO:0098772
GO:0106015
GO:0106016
GO:0106091
GO:1900026
GO:1903039
GO:1904036
GO:1904399
GO:1904996
GO:1905555
GO:1905564
GO:1905653
GO:2000179
GO:2000347
GO:2000391
GO:2001224
HMNXSV003009522
HMNXSV003046708
ILMN_1659142
ILMN_1706440
ILMN_1723087
ILMN_1724977
ILMN_2261876
ILMN_2349393
M94250_at
PH_hs_0004689
PH_hs_0014242
TC11000397.hg
g182650_3p_at
g4503316_3p_a_at
Participates
as a member of
PTN,MDK [extracellular region] (Homo sapiens)
as a component of
MDK:p-7Y ALK dimer [plasma membrane] (Homo sapiens)
MDK:ALK [plasma membrane] (Homo sapiens)
MDK:ALK dimer [plasma membrane] (Homo sapiens)
MDK [extracellular region] (Homo sapiens)
as an input of
ALK binds ligand midkine (MDK) (Homo sapiens)
Inferred To
mdk [extracellular region]
(Xenopus tropicalis)
mdkb [extracellular region]
(Danio rerio)
MDK [extracellular region]
(Bos taurus)
MDK [extracellular region]
(Canis familiaris)
MDK [extracellular region]
(Gallus gallus)
MDK [extracellular region]
(Sus scrofa)
Mdk [extracellular region]
(Mus musculus)
Mdk [extracellular region]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000110492
ENSEMBL
ENSP00000384034
,
ENST00000395569
,
ENSP00000378932
,
ENSP00000378933
,
ENST00000359803
,
ENSP00000385451
,
ENST00000407067
,
ENST00000405308
,
ENSP00000352852
,
ENSP00000378936
,
ENST00000395566
,
ENST00000395565
HPA
ENSG00000110492-MDK
ZINC - Substances
MK_HUMAN
ZINC target
P21741
PRO
P21741
Pharos - Targets
P21741
GlyGen
P21741
HMDB Protein
HMDBP02563
PDB
1MKN
,
1MKC
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UMS0 NFU1
1
NFU1 [mitochondrial matrix]
(R-HSA-1362393)
0.556
3
UniProt:P08631-2 HCK
0.556
3
UniProt:Q96AL5 Q96AL5
0.556
3
UniProt:Q9BXS5 AP1M1
7
AP1M1 [cytoplasmic vesicle membrane]
(R-HSA-351196)
AP1M1 [Golgi membrane]
(R-HSA-350805)
AP1M1 [lysosomal membrane]
(R-HSA-432708)
AP1M1 [trans-Golgi network membrane]
(R-HSA-2130512)
AP1M1 [cytosol]
(R-HSA-167700)
AP1M1 [plasma membrane]
(R-HSA-6806311)
AP1M1 [specific granule membrane]
(R-HSA-6799365)
0.556
3
UniProt:Q6PL24 TMED8
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:Q96C03-3 MIEF2
0.556
3
UniProt:Q8TAC2 JOSD2
1
JOSD2 [cytosol]
(R-HSA-5688775)
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:Q15560 TCEA2
0.556
3
UniProt:Q8N0V3 RBFA
0.556
3
UniProt:Q8NFC6 BOD1L1
1
BOD1L1 [nucleoplasm]
(R-HSA-8954547)
0.527
2
UniProt:Q9UQ35 SRRM2
1
SRRM2 [nucleoplasm]
(R-HSA-8865888)
0.527
2
UniProt:Q13427 PPIG
2
PPIG [nucleoplasm]
(R-HSA-9769592)
PPIG [cytosol]
(R-HSA-9728768)
0.527
2
UniProt:Q9UHB7 AFF4
1
AFF4 [nucleoplasm]
(R-HSA-8932788)
0.527
2
UniProt:Q9HCG8 CWC22
1
CWC22 [nucleoplasm]
(R-HSA-8865956)
0.527
2
UniProt:O15417 TNC18
0.527
2
UniProt:P62979 RPS27A
20
RPS27A(1-76) [endocytic vesicle membrane]
(R-HSA-939208)
RPS27A(77-156) [nucleoplasm]
(R-HSA-6798734)
Ub-33-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783024)
Ub-63-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783200)
Ub-6-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783040)
Ub-11-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783085)
Ub-48-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783075)
Ub-29-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783146)
Ub-63-RPS27A(1-76) [cytosol]
(R-HSA-939248)
RPS27A(1-76) [lysosomal lumen]
(R-HSA-9660001)
RPS27A(1-76) [cytosol]
(R-HSA-939205)
p-S65-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-9834951)
Ub-48-RPS27A(1-76) [cytosol]
(R-HSA-939202)
RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-9834993)
RPS27A(1-76) [late endosome lumen]
(R-HSA-9660022)
Ub-6-RPS27A(1-76) [nucleoplasm]
(R-HSA-6782608)
Ub-63-RPS27A(1-76) [nucleoplasm]
(R-HSA-6782503)
Ub-48-RPS27A(1-76) [nucleoplasm]
(R-HSA-5683037)
RPS27A(1-76) [nucleoplasm]
(R-HSA-939849)
Ub-11-RPS27A(1-76) [cytosol]
(R-HSA-3095933)
0.527
2
UniProt:P43378 PTPN9
1
PTPN9 [nucleoplasm]
(R-HSA-9008907)
0.527
2
UniProt:Q9H307 PNN
1
PNN [nucleoplasm]
(R-HSA-9770779)
0.527
2
UniProt:Q02539 H1-1
1
HIST1H1A [nucleoplasm]
(R-HSA-211245)
0.527
2
UniProt:P42568 MLLT3
1
MLLT3 [nucleoplasm]
(R-HSA-8932789)
0.527
2
UniProt:Q9BUL9 RPP25
1
RPP25 [nucleoplasm]
(R-HSA-5696782)
0.527
2
UniProt:O15047 SETD1A
1
SETD1A [nucleoplasm]
(R-HSA-3239027)
0.527
2
UniProt:Q96HR8 NAF1
0.527
2
UniProt:Q8WVZ9 KBTBD7
1
KBTBD7 [cytosol]
(R-HSA-5658415)
0.527
2
UniProt:O75052 CAPON
0.527
2
UniProt:Q9NRR5 UBQL4
0.488
2
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