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SIRT2 [cytosol]
Stable Identifier
R-HSA-2161118
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NAD-dependent deacetylase sirtuin-2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
ANKLE2 is deacetylated by SIRT2 (Homo sapiens)
SIRT2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IXJ6 SIRT2
Gene Names
SIRT2, SIR2L, SIR2L2
Chain
initiator methionine:, chain:2-389
Reference Genes
BioGPS Gene:22933 SIRT2
COSMIC (genes):SIRT2 SIRT2
CTD Gene:22933 SIRT2
dbSNP Gene:22933 SIRT2
ENSEMBL:ENSG00000068903 SIRT2
ENSEMBL_homo_sapiens_GENE:ENSG00000068903.21 SIRT2
ENSEMBL_homo_sapiens_GENE:ENSG00000283100.2 SIRT2
HGNC:10886 SIRT2
KEGG Gene (Homo sapiens):22933 SIRT2
Monarch:22933 SIRT2
NCBI Gene:22933 SIRT2
OMIM:604480 SIRT2
UCSC:Q8IXJ6 SIRT2
Reference Transcript
RefSeq:XM_006723111.1 SIRT2
RefSeq:NM_012237.3 SIRT2
RefSeq:XM_011526655.1 SIRT2
RefSeq:NM_030593.2 SIRT2
RefSeq:NM_001193286.1 SIRT2
RefSeq:XM_011526654.1 SIRT2
Other Identifiers
11715768_x_at
11748220_a_at
16872089
220605_PM_s_at
220605_s_at
22933
3861690
3861691
3861692
3861693
3861694
3861696
3861697
3861700
3861701
3861702
3861703
3861704
3861705
3861707
3861708
3861710
3861711
3861712
3861714
3861721
3861725
3861726
56491_at
8036636
A_23_P142455
A_33_P3258946
A_33_P3271800
GE58472
GO:0000122
GO:0000183
GO:0000278
GO:0000781
GO:0000792
GO:0002376
GO:0003682
GO:0003824
GO:0003950
GO:0004407
GO:0005515
GO:0005634
GO:0005677
GO:0005694
GO:0005730
GO:0005737
GO:0005739
GO:0005813
GO:0005814
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006476
GO:0006629
GO:0006914
GO:0007049
GO:0007059
GO:0007084
GO:0007096
GO:0007399
GO:0008270
GO:0010507
GO:0010801
GO:0012501
GO:0016020
GO:0016575
GO:0016740
GO:0016787
GO:0017136
GO:0021762
GO:0022011
GO:0022414
GO:0030154
GO:0030163
GO:0030426
GO:0030496
GO:0031507
GO:0031509
GO:0031641
GO:0032200
GO:0032436
GO:0033010
GO:0033270
GO:0033558
GO:0034599
GO:0034979
GO:0034983
GO:0035035
GO:0036211
GO:0040029
GO:0042177
GO:0042325
GO:0042826
GO:0042903
GO:0042995
GO:0043130
GO:0043161
GO:0043204
GO:0043209
GO:0043219
GO:0043220
GO:0043226
GO:0043388
GO:0044224
GO:0044242
GO:0044546
GO:0045087
GO:0045598
GO:0045599
GO:0045723
GO:0045836
GO:0045843
GO:0045892
GO:0045944
GO:0046872
GO:0046970
GO:0048471
GO:0048856
GO:0051287
GO:0051301
GO:0051321
GO:0051726
GO:0051775
GO:0051781
GO:0051987
GO:0061024
GO:0061433
GO:0065003
GO:0070403
GO:0070446
GO:0071456
GO:0071872
GO:0072686
GO:0072687
GO:0090042
GO:0097386
GO:0098542
GO:0140013
GO:0140014
GO:0140096
GO:0140297
GO:0140773
GO:0140774
GO:1900119
GO:1900195
GO:1900226
GO:2000378
HMNXSV003021571
ILMN_1723494
ILMN_2398711
PH_hs_0018233
TC19002477.hg
g13775599_3p_s_at
Inferred To
SIRT2 [cytosol]
(Bos taurus)
SIRT2 [cytosol]
(Canis familiaris)
SIRT2 [cytosol]
(Danio rerio)
SIRT2 [cytosol]
(Drosophila melanogaster)
SIRT2 [cytosol]
(Gallus gallus)
SIRT2 [cytosol]
(Mus musculus)
SIRT2 [cytosol]
(Rattus norvegicus)
SIRT2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001180215.1
,
XP_006723174.1
,
NP_085096.1
,
XP_011524957.1
,
NP_036369.2
,
XP_011524956.1
ZINC - World Drugs
SIR2_HUMAN
Guide to Pharmacology - Targets
2708
OpenTargets
ENSG00000068903
ZINC - FDA approved
SIR2_HUMAN
ZINC - Substances
SIR2_HUMAN
ZINC target
Q8IXJ6
ZINC - Biogenic
SIR2_HUMAN
PRO
Q8IXJ6
PDB
4X3O
,
4RMG
,
6QCN
,
5DY4
,
4Y6Q
,
4R8M
,
6NR0
,
4RMI
,
5Y5N
,
4L3O
,
6L65
,
5YQO
,
4X3P
,
4RMH
,
6L66
,
5DY5
,
5Y0Z
,
8TGP
,
6L72
,
5G4C
,
5YQM
,
5FYQ
,
3ZGO
,
5YQN
,
4RMJ
,
5D7Q
,
8OWZ
,
5MAR
,
4Y6O
,
1J8F
,
5D7P
,
5MAT
,
3ZGV
,
7BOS
,
4Y6L
,
7BOT
,
5D7O
,
5YQL
,
6L71
ZINC - Investigational
SIR2_HUMAN
ZINC - Metabolites
SIR2_HUMAN
GeneCards
Q8IXJ6
HPA
ENSG00000068903-SIRT2
Ensembl
ENSP00000489602
,
ENSG00000068903
,
ENSP00000375931
,
ENST00000634533
,
ENSP00000249396
,
ENSP00000488940
,
ENST00000249396
,
ENST00000635478
,
ENSG00000283100
,
ENST00000392081
Pharos - Targets
Q8IXJ6
ZINC - Predictions - Purchasable
SIR2_HUMAN
HMDB Protein
HMDBP08880
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60566 BUB1B
1
BUB1B [cytosol]
(R-HSA-141436)
0.576
3
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.576
4
UniProt:P49591 SARS1
1
SARS [cytosol]
(R-HSA-379691)
0.564
3
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.544
2
UniProt:P11413 G6PD
1
G6PD [cytosol]
(R-HSA-70372)
0.524
3
UniProt:O60729 CDC14B
1
CDC14B [nucleoplasm]
(R-HSA-3214897)
0.524
2
UniProt:Q9BYB0 SHANK3
1
SHANK3 [cytosol]
(R-HSA-6794277)
0.508
2
UniProt:Q9UBN7 HDAC6
4
HDAC6 [nucleoplasm]
(R-HSA-351589)
HDAC6 [late endosome lumen]
(R-HSA-9659980)
HDAC6 [cytosol]
(R-HSA-5324660)
HDAC6 [lysosomal lumen]
(R-HSA-9660002)
0.463
2
UniProt:P15172 MYOD1
1
MYOD1 [nucleoplasm]
(R-HSA-445441)
0.462
2
UniProt:Q9UM11 FZR1
4
FZR1 [cytosol]
(R-HSA-174249)
FZR1 [nucleoplasm]
(R-HSA-174099)
p-FZR1 [nucleoplasm]
(R-HSA-174257)
p-FZR1 [cytosol]
(R-HSA-174193)
0.462
2
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