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EFEMP2 [extracellular region]
Stable Identifier
R-HSA-2161231
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
FBLN4, Fibulin-4, EGF-containing fibulin-like extracellular matrix protein 2
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Elastic fibre formation (Homo sapiens)
Molecules associated with elastic fibres (Homo sapiens)
Elastic fibres bind associated proteins (Homo sapiens)
Elastic fibre with associated proteins [extracellular region] (Homo sapiens)
Elastic fibre:Fibulins:Emilins [extracellular region] (Homo sapiens)
Elastic fibre:Fibulins [extracellular region] (Homo sapiens)
Fibulins [extracellular region] (Homo sapiens)
EFEMP2 [extracellular region] (Homo sapiens)
Elastic fibre:Fibulins:Emilins [extracellular region] (Homo sapiens)
Elastic fibre:Fibulins [extracellular region] (Homo sapiens)
Fibulins [extracellular region] (Homo sapiens)
EFEMP2 [extracellular region] (Homo sapiens)
Emilin is found in elastic fibres (Homo sapiens)
Elastic fibre:Fibulins [extracellular region] (Homo sapiens)
Fibulins [extracellular region] (Homo sapiens)
EFEMP2 [extracellular region] (Homo sapiens)
Elastic fibre:Fibulins:Emilins [extracellular region] (Homo sapiens)
Elastic fibre:Fibulins [extracellular region] (Homo sapiens)
Fibulins [extracellular region] (Homo sapiens)
EFEMP2 [extracellular region] (Homo sapiens)
Fibulin binds elastic fibres (Homo sapiens)
Elastic fibre:Fibulins [extracellular region] (Homo sapiens)
Fibulins [extracellular region] (Homo sapiens)
EFEMP2 [extracellular region] (Homo sapiens)
Fibulins [extracellular region] (Homo sapiens)
EFEMP2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95967 EFEMP2
Gene Names
EFEMP2, FBLN4, UNQ200/PRO226
Chain
signal peptide:1-25, chain:26-443
Reference Genes
BioGPS Gene:30008 EFEMP2
COSMIC (genes):EFEMP2 EFEMP2
CTD Gene:30008 EFEMP2
dbSNP Gene:30008 EFEMP2
ENSEMBL:ENSG00000172638 EFEMP2
HGNC:3219 EFEMP2
KEGG Gene (Homo sapiens):30008 EFEMP2
Monarch:30008 EFEMP2
NCBI Gene:30008 EFEMP2
OMIM:604633 EFEMP2
UCSC:O95967 EFEMP2
Reference Transcript
RefSeq:NM_016938.4 EFEMP2
Other Identifiers
0007050487
11728351_a_at
11728352_x_at
11750280_x_at
16740577
206580_s_at
209356_x_at
30008
3377934
3377935
3377936
3377937
3377938
3377939
3377940
3377943
3377944
3377945
3377947
3377949
3377951
3377952
3377953
3377955
3377956
3377959
3377960
3377962
35347_at
63644_at
7949503
A_23_P24414
A_33_P3367830
GE54811
GO:0003674
GO:0005198
GO:0005201
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005604
GO:0005615
GO:0008150
GO:0022607
GO:0030198
GO:0031012
GO:0043167
GO:0043226
GO:0048251
GO:0062023
GO:0070062
GO:1903561
ILMN_1653203
PH_hs_0018623
TC11001946.hg
TC11003210.hg
g7328920_3p_a_at
Participant Of
hasMember
Fibulins [extracellular region]
Inferred To
efemp2a [extracellular region] (Danio rerio)
Efemp2 [extracellular region] (Mus musculus)
Efemp2 [extracellular region] (Rattus norvegicus)
efemp2 [extracellular region] (Xenopus tropicalis)
EFEMP2 [extracellular region] (Bos taurus)
EFEMP2 [extracellular region] (Canis familiaris)
EFEMP2 [extracellular region] (Dictyostelium discoideum)
frac [extracellular region] (Drosophila melanogaster)
CT7856 [extracellular region] (Drosophila melanogaster)
BcDNA:RE64043 [extracellular region] (Drosophila melanogaster)
nid-1 [extracellular region] (Caenorhabditis elegans)
Homologues of EFEMP2 [extracellular region] (Dictyostelium discoideum)
Homologues of EFEMP2 [extracellular region] (Drosophila melanogaster)
Cross References
RefSeq
NP_058634.4
OpenTargets
ENSG00000172638
HPA
ENSG00000172638-EFEMP2
GeneCards
O95967
Ensembl
ENST00000307998
,
ENST00000531972
,
ENSP00000435295
,
ENSP00000309953
,
ENSG00000172638
PRO
O95967
Orphanet
15914
PDB
2KL7
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15502 ELN
3
ELN(?-786) [extracellular region]
(R-HSA-2514775)
ELN(27-?) [extracellular region]
(R-HSA-2514783)
ELN [extracellular region]
(R-HSA-1454880)
0.645
5
UniProt:P35555 FBN1
7
FBN1 [endoplasmic reticulum lumen]
(R-HSA-8956726)
FBN1 [extracellular region]
(R-HSA-265402)
p-FBN1 [endoplasmic reticulum lumen]
(R-HSA-8956900)
FBN1(28-2731) [extracellular region]
(R-HSA-2159853)
FBN1(28-?) [extracellular region]
(R-HSA-2514785)
FBN1(1-2731) [extracellular region]
(R-HSA-2514817)
FBN1(2732-2871) [extracellular region]
(R-HSA-2159838)
0.611
3
UniProt:Q9UBX5 FBLN5
1
FBLN5 [extracellular region]
(R-HSA-2161278)
0.611
3
UniProt:P24592 IGFBP6
1
IGFBP6 [extracellular region]
(R-HSA-381475)
0.556
3
UniProt:P10745 RBP3
1
RBP3 [extracellular region]
(R-HSA-2984190)
0.556
3
UniProt:P56524 HDAC4
3
SUMO1-K559-HDAC4 [nucleoplasm]
(R-HSA-4616016)
SUMO2,3-K559-HDAC4 [nucleoplasm]
(R-HSA-4616029)
HDAC4 [nucleoplasm]
(R-HSA-351581)
0.556
3
UniProt:Q99572 P2RX7
1
P2RX7 [plasma membrane]
(R-HSA-877215)
0.556
3
UniProt:P01024 C3
22
C3c alpha' chain fragment 1 precursor [extracellular region]
(R-HSA-976816)
C3d fragment [extracellular region]
(R-HSA-198999)
C3c alpha' chain fragment 2 [extracellular region]
(R-HSA-976818)
C3c alpha' chain fragment 1 [extracellular region]
(R-HSA-3266502)
C3a-desArg [extracellular region]
(R-HSA-8852808)
C3dg [plasma membrane]
(R-HSA-3266505)
C3d [plasma membrane]
(R-HSA-8853248)
C3f [extracellular region]
(R-HSA-976779)
C3 beta chain [plasma membrane]
(R-HSA-977593)
C3c alpha' chain fragment 1 precursor [plasma membrane]
(R-HSA-977595)
C3c alpha' chain fragment 2 [plasma membrane]
(R-HSA-977594)
C3 alpha chain [azurophil granule lumen]
(R-HSA-6799161)
C3 beta chain [azurophil granule lumen]
(R-HSA-6799159)
C3 alpha chain [secretory granule lumen]
(R-HSA-6800982)
C3 beta chain [secretory granule lumen]
(R-HSA-6801014)
p-C3 [endoplasmic reticulum lumen]
(R-HSA-8957056)
C3 [endoplasmic reticulum lumen]
(R-HSA-8956774)
C3 alpha chain [extracellular region]
(R-HSA-166820)
dNQ-C3(672-1663) [extracellular region]
(R-HSA-182452)
C3b alpha' [extracellular region]
(R-HSA-166830)
C3 beta chain [extracellular region]
(R-HSA-166821)
C3a [extracellular region]
(R-HSA-166828)
0.556
3
UniProt:Q9H2F3 HSD3B7
1
HSD3B7 [endoplasmic reticulum membrane]
(R-HSA-193441)
0.556
3
UniProt:Q96RU7 TRIB3
3
TRIB3 [cytosol]
(R-HSA-162411)
TRIB3 [plasma membrane]
(R-HSA-199447)
TRIB3 [nucleoplasm]
(R-HSA-9635877)
0.556
3
UniProt:P09022 Hoxa1
1
Hoxa1 [nucleoplasm]
(R-MMU-5617924)
0.508
3
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