Reactome | EFEMP2 [extracellular region]

EFEMP2 [extracellular region]

Stable Identifier

R-HSA-2161231

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

FBLN4, Fibulin-4, EGF-containing fibulin-like extracellular matrix protein 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O95967 EFEMP2

Gene Names

EFEMP2, FBLN4, UNQ200/PRO226

Chain

signal peptide:1-25, chain:26-443

Reference Genes

BioGPS Gene:30008 EFEMP2

COSMIC (genes):EFEMP2 EFEMP2

CTD Gene:30008 EFEMP2

dbSNP Gene:30008 EFEMP2

ENSEMBL:ENSG00000172638 EFEMP2

HGNC:3219 EFEMP2

KEGG Gene (Homo sapiens):30008 EFEMP2

Monarch:30008 EFEMP2

NCBI Gene:30008 EFEMP2

OMIM:604633 EFEMP2

UCSC:O95967 EFEMP2

Reference Transcript

RefSeq:NM_016938.4 EFEMP2

Other Identifiers

0007050487

11728351_a_at

11728352_x_at

11750280_x_at

16740577

206580_s_at

209356_x_at

23270

2KL7

30008

3377934

3377935

3377936

3377937

3377938

3377939

3377940

3377943

3377944

3377945

3377947

3377949

3377951

3377952

3377953

3377955

3377956

3377959

3377960

3377962

35347_at

63644_at

7949503

A0A024R5G1

A_23_P24414

A_33_P3367830

AAC62108

AAF65188

AAH10456

AAQ89258

AF093119

AF109121

AJ132819

AK000980

AK075453

AK292079

AP001201

AY358899

BAF84768

BAG50843

BAG52143

BC010456

CAA10791

CCDS8116

CH471076

E9PI47

E9PKA3

E9PNB8

E9PRQ8

E9PRU1

E9PSC1

EAW74455

EAW74456

EAW74457

EAW74458

EAW74459

EAW74461

EAW74462

EFEMP2

EFEMP2-201

EFEMP2-217

ENSG00000172638

ENSP00000309953

ENSP00000435295

ENST00000307998

ENST00000307998.10

ENST00000531972

ENST00000531972.5

EntrezGene:30008

EntrezGene:EFEMP2

g7328920_3p_a_at

GE54811

GO:0003674

GO:0005198

GO:0005201

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005604

GO:0005615

GO:0008150

GO:0022607

GO:0030198

GO:0031012

GO:0043167

GO:0043226

GO:0048251

GO:0062023

GO:0070062

GO:1903561

H0YET5

H0YEU0

HGNC:3219

HPA023270

ILMN_1653203

IPR000152

IPR000742

IPR001881

IPR009030

IPR013032

IPR018097

IPR026823

IPR026824

MIM:604633

MIM:614437

NM_016938

NP_058634

NR_037718

PF07645

PF12662

PH_hs_0018623

PR00907

SM00179

SM00181

TC11001946.hg

TC11003210.hg

UPI000013EC97

Participant Of

hasMember

Fibulins [extracellular region]

Inferred To

EFEMP2 [extracellular region] (Bos taurus)

EFEMP2 [extracellular region] (Canis familiaris)

EFEMP2 [extracellular region] (Danio rerio)

EFEMP2 [extracellular region] (Dictyostelium discoideum)

EFEMP2 [extracellular region] (Mus musculus)

EFEMP2 [extracellular region] (Rattus norvegicus)

EFEMP2 [extracellular region] (Xenopus tropicalis)

Homologues of EFEMP2 [extracellular region] (Dictyostelium discoideum)

Cross References

RefSeq

NP_058634.4

OpenTargets

ENSG00000172638

GeneCards

O95967

PRO

O95967

Orphanet

15914

PDB

2KL7

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15502 ELN	3	ELN(?-786) [extracellular region] (R-HSA-2514775) ELN(27-?) [extracellular region] (R-HSA-2514783) ELN [extracellular region] (R-HSA-1454880)	0.645	5
UniProt:Q9UBX5 FBLN5	1	FBLN5 [extracellular region] (R-HSA-2161278)	0.611	3
UniProt:P35555 FBN1	7	FBN1(1-2731) [extracellular region] (R-HSA-2514817) FBN1(2732-2871) [extracellular region] (R-HSA-2159838) FBN1(28-?) [extracellular region] (R-HSA-2514785) FBN1(28-2731) [extracellular region] (R-HSA-2159853) p-FBN1 [endoplasmic reticulum lumen] (R-HSA-8956900) FBN1 [endoplasmic reticulum lumen] (R-HSA-8956726) FBN1 [extracellular region] (R-HSA-265402)	0.611	3
UniProt:P56524 HDAC4	3	SUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) SUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) HDAC4 [nucleoplasm] (R-HSA-351581)	0.556	3
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.508	3
UniProt:P10745 RBP3	1	RBP3 [extracellular region] (R-HSA-2984190)	0.488	2
UniProt:Q99572 P2RX7	1	P2RX7 [plasma membrane] (R-HSA-877215)	0.488	2
UniProt:P01024 C3	22	C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3d fragment [extracellular region] (R-HSA-198999) C3dg [plasma membrane] (R-HSA-3266505) C3d [plasma membrane] (R-HSA-8853248) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3f [extracellular region] (R-HSA-976779) C3 beta chain [plasma membrane] (R-HSA-977593) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3a-desArg [extracellular region] (R-HSA-8852808) C3 alpha chain [azurophil granule lumen] (R-HSA-6799161) C3 beta chain [azurophil granule lumen] (R-HSA-6799159) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [secretory granule lumen] (R-HSA-6801014) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) C3 alpha chain [extracellular region] (R-HSA-166820) C3b alpha' [extracellular region] (R-HSA-166830) C3 beta chain [extracellular region] (R-HSA-166821) dNQ-C3(672-1663) [extracellular region] (R-HSA-182452) C3a [extracellular region] (R-HSA-166828)	0.488	2
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.488	2
UniProt:Q96RU7 TRIB3	3	TRIB3 [cytosol] (R-HSA-162411) TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.488	2
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.488	2