Abacavir transmembrane transport

Stable Identifier
R-HSA-2161517
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Cytosolic levels of abacavir are determined by the balance of its facilitated diffusion into the cell mediated by organic cation transporters SLC22A1, 2, and 3, and its ATP-dependent efflux from cells mediated by ABCG2 and ABCB1 (Klaasen and Aleksunes 2010; Pan et al. 2007; Shaik et al. 2007).

Literature References
PubMed ID Title Journal Year
17709369 P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution

Shaik, N, Giri, N, Pan, G, Elmquist, WF

Drug Metab Dispos 2007
20103563 Xenobiotic, bile acid, and cholesterol transporters: function and regulation

Klaassen, CD, Aleksunes, LM

Pharmacol Rev 2010
17437964 Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine

Pan, G, Giri, N, Elmquist, WF

Drug Metab Dispos 2007
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created