Abacavir metabolism

Stable Identifier
R-HSA-2161541
Type
Pathway
Species
Homo sapiens
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Abacavir activation proceeds steps of phosphorylation, deamination to yield carbovir monophosphate, and phosphorylation of the latter compound to yield the triphosphate. In addition, abacavir can be conjugated with glucuronide or oxidized to its 5'-carboxylate derivative, the two major forms in which it is excreted from the body (Yuen et al. 2008).

Literature References
PubMed ID Title Journal Year
18479171 A review of the pharmacokinetics of abacavir

Yuen, GJ, Weller, S, Pakes, GE

Clin Pharmacokinet 2008
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Participant Of
Event Information
Go Biological Process
Orthologous Events
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