LTB4 is oxidised to 12-oxoLTB4 by PTGR1

Stable Identifier
Reaction [transition]
Homo sapiens
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Prostaglandin reductase 1 (PTGR1) aka LTB4DH metabolizes eicosanoids by catalysing the oxidation of leukotriene B4 (LTB4) to form 12-oxo-Leukotriene B4 (12-oxoLTB4) aka 12-Keto-LTB4. The gene was originally cloned as leukotriene B4 12-hydroxydehydrogenase (LTB4DH) but was later discovered to have dual functionality as a prostaglandin reductase (Yokomizo et al. 1996). This reaction has been inferred from a reaction in pigs (Yokomizo et al. 1993, Ensor et al. 1998).

Literature References
PubMed ID Title Journal Year
9461497 Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung

Tai, HH, Zhang, H, Ensor, CM

Biochem J 1998
8394361 Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase

Takahashi, T, Kasama, T, Yokomizo, T, Sato, F, Kobayashi, Y, Taketani, Y, Izumi, T, Shimizu, T

J Biol Chem 1993
8576264 cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase

Kume, K, Uozumi, N, Ogawa, Y, Yokomizo, T, Izumi, T, Shimizu, T

J Biol Chem 1996
Catalyst Activity

leukotriene B4 12-hydroxy dehydrogenase activity of PTGR1 [cytosol]

Inferred From
Cross References
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