LTB4 is oxidised to 12-oxoLTB4 by PTGR1

Stable Identifier
R-HSA-2161567
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Prostaglandin reductase 1 (PTGR1) aka LTB4DH metabolizes eicosanoids by catalysing the oxidation of leukotriene B4 (LTB4) to form 12-oxo-Leukotriene B4 (12-oxoLTB4) aka 12-Keto-LTB4. The gene was originally cloned as leukotriene B4 12-hydroxydehydrogenase (LTB4DH) but was later discovered to have dual functionality as a prostaglandin reductase (Yokomizo et al. 1996). This reaction has been inferred from a reaction in pigs (Yokomizo et al. 1993, Ensor et al. 1998).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
leukotriene B4 12-hydroxy dehydrogenase activity of PTGR1 [cytosol]
Physical Entity
Activity
Inferred From
Cross References
Rhea