PGH2 is reduced to PGF2a by FAM213B

Stable Identifier
R-HSA-2161612
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Prostamide/prostaglandin F synthase, FAM213B and thioredoxin (TXN) are the proteins involved in the reduction of prostaglandin H2 (PGH2) to prostaglandin F2alpha (PGF2a) (Moriuchi et al. 2008, Yoshikawa et al. 2011). This reaction has been inferred from an event in mice. An additional way of achieving this reaction involves the protein aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS.

Literature References
PubMed ID Title Journal Year
20950588 Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system

Yoshikawa, K, Takei, S, Hasegawa-Ishii, S, Chiba, Y, Furukawa, A, Kawamura, N, Hosokawa, M, Woodward, DF, Watanabe, K, Shimada, A

Brain Res 2011
18006499 Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily

Moriuchi, H, Koda, N, Okuda-Ashitaka, E, Daiyasu, H, Ogasawara, K, Toh, H, Ito, S, Woodward, DF, Watanabe, K

J Biol Chem 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thioredoxin peroxidase activity of FAM213B [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed