PGD2 is reduced to 11-epi-PGF2a by AKRIC3

Stable Identifier
R-HSA-2161614
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PGD2 is reduced to 11-epi-PGF2a by AKRIC3
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Aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS is the enzyme involved in NADPH-dependent prostaglandin D2 11-keto reductase activity of reducing prostaglandin D2 (PGD2) to 11-epi-Prostaglandin F2alpha (11-epi-PGF2a) (Liston & Roberts 1985, Koda et al. 2004).
Literature References
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Output
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Catalyst Activity

prostaglandin D2 11-ketoreductase activity of AKR1C3 [cytosol]

Physical Entity
AKR1C3 [cytosol] (Homo sapiens)
Activity
prostaglandin D2 11-ketoreductase activity (GO:0036131)
Orthologous Events
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Bos taurus)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Caenorhabditis elegans)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Dictyostelium discoideum)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Drosophila melanogaster)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Mus musculus)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Rattus norvegicus)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Saccharomyces cerevisiae)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Schizosaccharomyces pombe)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Sus scrofa)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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