PGH2 is isomerised to PGD2 by PTGDS

Stable Identifier
R-HSA-2161620
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Prostaglandin D2 (PGD2) is a structural isomer of prostaglandin E2 (PGE2). There is a 9-keto and 11-hydroxy group on PGE2 with these substituents reversed on PGD2. PGD2 is formed by two evolutionarily distinct, but functionally convergent, prostaglandin D synthases: lipocalin-type prostaglandin-D synthase aka Prostaglandin-H2 D-isomerase (PTDGS) and hematopoietic prostaglandin D synthase (HPGDS). One of the main differences between these two proteins is that HPGDS requires glutathione (GSH) for catalysis while PTDGS can function without this cofactor. Here, PTDGS promotes the isomerisation of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2) (Zhou et al. 2010).

Literature References
PubMed ID Title Journal Year
20667974 Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules

Zhou, Y, Shaw, N, Li, Y, Zhao, Y, Zhang, R, Liu, ZJ

FASEB J 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
prostaglandin-D synthase activity of PTGDS [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed