PGH2 is isomerised to PGE2 by PTGES

Stable Identifier
R-HSA-2161660
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Prostaglandin E synthase (PTGES) requires glutathione (GSH) as an essential cofactor for its enzymatic activity, and together they isomerise prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2) (Jegerschold et al. 2008). After PGH2 has been produced by the prostaglandin G/H synthases (PTGS1 and 2) on the lumenal side of the endoplasmic reticulum, it diffuses through the membrane to the active site of PTGES located on the cytoplasmic side.

Literature References
PubMed ID Title Journal Year
18682561 Structural basis for induced formation of the inflammatory mediator prostaglandin E2

Jegerschöld, C, Pawelzik, SC, Purhonen, P, Bhakat, P, Gheorghe, KR, Gyobu, N, Mitsuoka, K, Morgenstern, R, Jakobsson, PJ, Hebert, H

Proc Natl Acad Sci U S A 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
prostaglandin-E synthase activity of PTGES trimer [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed