PGH2 is isomerised to PGD2 by HPGDS

Stable Identifier
R-HSA-2161701
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Prostaglandin D2 (PGD2) is a structural isomer of prostaglandin E2 (PGE2). There is a 9-keto and 11-hydroxy group on PGE2 with these substituents reversed on PGD2. PGD2 is formed by two evolutionarily distinct, but functionally convergent, prostaglandin D synthases: lipocalin-type prostaglandin-D synthase aka Prostaglandin-H2 D-isomerase (PTDGS) and hematopoietic prostaglandin D synthase (HPGDS). One of the main differences between these two proteins is that HPGDS requires glutathione (GSH) for catalysis while PTDGS can function without this cofactor. Here, HPGDS with GSH promotes the isomerisation of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2) (Jowsey et al. 2001, Inoue et al. 2003).

Literature References
PubMed ID Title Journal Year
12627223 Mechanism of metal activation of human hematopoietic prostaglandin D synthase

Inoue, T, Irikura, D, Okazaki, N, Kinugasa, S, Matsumura, H, Uodome, N, Yamamoto, M, Kumasaka, T, Miyano, M, Kai, Y, Urade, Y

Nat Struct Biol 2003
11672424 Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases

Jowsey, IR, Thomson, AM, Flanagan, JU, Murdock, PR, Moore, GB, Meyer, DJ, Murphy, GJ, Smith, SA, Hayes, JD

Biochem J 2001
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Catalyst Activity
Catalyst Activity
Title
prostaglandin-D synthase activity of HPGDS dimer [cytosol]
Physical Entity
Activity
Orthologous Events
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Created