EXA4 is converted to EXC4 by LTC4S

Stable Identifier
R-HSA-2161768
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In addition to its role converting leukotriene A4 (LTA4) into leukotriene C4 (LTC4), the enzyme leukotriene C4 synthase (LTC4S) analogously converts eoxin A4 (EXA4), with reduced glutathione (GSH), to eoxin C4 (EXC4) (Feltenmark et al. 2008, Claesson et al. 2008).

Literature References
PubMed ID Title Journal Year
18647347 Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma

Claesson, HE, Griffiths, WJ, Brunnström, A, Schain, F, Andersson, E, Feltenmark, S, Johnson, HA, Porwit, A, Sjöberg, J, Björkholm, M

FEBS J 2008
18184802 Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells

Feltenmark, S, Gautam, N, Brunnström, A, Griffiths, W, Backman, L, Edenius, C, Lindbom, L, Björkholm, M, Claesson, HE

Proc Natl Acad Sci U S A 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
eoxin C4 synthase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed