Reactome: A Curated Pathway Database

EXA4 is converted to EXC4 by LTC4S

Stable Identifier
R-HSA-2161768
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In addition to its role converting leukotriene A4 (LTA4) into leukotriene C4 (LTC4), the enzyme leukotriene C4 synthase (LTC4S) analogously converts eoxin A4 (EXA4), with reduced glutathione (GSH), to eoxin C4 (EXC4) (Feltenmark et al. 2008, Claesson et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
eoxin C4 synthase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope] ALOX5:ALOX5AP:LTC4S [nuclear envelope] eoxin C4 synthase activity (0097261)
Orthologous Events