20cooh-LTB4 is converted to 18cooh-LTB4

Stable Identifier
R-HSA-2161790
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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Summation

Once omega-oxidation has occurred, 20-carboxy leukotriene B4 (20cooh-LTB4) can be further metabolized by beta-oxidation at its omega end into 18-carboxy-LTB4 (18cooh-LTB4) (Berry et al. 2003, Wheelan et al. 1999). The actual human enzyme or enzymes involved have yet to be identified.

Literature References
PubMed ID Title Journal Year
12709426 Urinary metabolites of leukotriene B4 in the human subject

Berry, KA, Borgeat, P, Gosselin, J, Flamand, L, Murphy, RC

J Biol Chem 2003
9862787 Metabolic transformations of leukotriene B4 in primary cultures of human hepatocytes

Wheelan, P, Hankin, JA, Bilir, B, Guenette, D, Murphy, RC

J Pharmacol Exp Ther 1999
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