EXD4 is converted to EXE4 by DPEP

Stable Identifier
Reaction [transition]
Homo sapiens
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In an analogous reaction to the formation of leukotriene E4 (LTE4), eoxin D4 (EXD4) is converted to eoxin E4 (EXE4) by a dipeptidase (DPEP) (Feltenmark et al. 2008, Claesson et al. 2008) which has not yet been identified.

Literature References
PubMed ID Title Journal Year
18184802 Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells

Griffiths, W, Brunnström, A, Edenius, C, Backman, L, Björkholm, M, Gautam, N, Lindbom, L, Claesson, HE, Feltenmark, S

Proc Natl Acad Sci U S A 2008
18647347 Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma

Brunnström, A, Björkholm, M, Johnson, HA, Griffiths, WJ, Sjöberg, J, Porwit, A, Claesson, HE, Schain, F, Feltenmark, S, Andersson, E

FEBS J 2008
Catalyst Activity

eoxin E4 synthase activity of DPEP [cytosol]

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