Reactome | Arachidonic acid is epoxidated to 5,6-EET by CYP(4)

Arachidonic acid is epoxidated to 5,6-EET by CYP(4)

Stable Identifier

R-HSA-2161890

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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Arachidonic acid is epoxidated to 5,6-EET by CYP(4)

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Several cytochrome P450s (CYPs) convert arachidonic acid to 5,6-epoxyeicosatrienoic acid (5,6-EET). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2J2 (Wu et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
8631948	Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart Falck, JR, Wu, S, Zeldin, DC, Moomaw, CR, Tomer, KB	J Biol Chem	1996
15258110	Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1 Stoilov, I, Choudhary, D, Schenkman, JB, Sarfarazi, M, Jansson, I	Drug Metab Dispos	2004