Arachidonic acid is epoxidated to 5,6-EET by CYP(4)

Stable Identifier
R-HSA-2161890
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Several cytochrome P450s (CYPs) convert arachidonic acid to 5,6-epoxyeicosatrienoic acid (5,6-EET). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2J2 (Wu et al. 1996).

Literature References
PubMed ID Title Journal Year
15258110 Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1

Choudhary, D, Jansson, I, Stoilov, I, Sarfarazi, M, Schenkman, JB

Drug Metab Dispos 2004
8631948 Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart

Wu, S, Moomaw, CR, Tomer, KB, Falck, JR, Zeldin, DC

J Biol Chem 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of CYP(4) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created