Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2

Stable Identifier
R-HSA-2161951
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aspirin acetylates the cyclooxygenase, prostaglandin G/H synthase 2 (PTGS2) aka COX2. The acetylated PTGS2 triggers the formation of 15R-hydroxyeicosatetraenoic acid (15R-HETE) from arachidonic acid (Claria & Serhan 1995).

Literature References
PubMed ID Title Journal Year
7568157 Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions

ClĂ ria, J, Serhan, CN

Proc Natl Acad Sci U S A 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
arachidonate 15-lipoxygenase activity of Ac-PTGS2 dimer [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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