EET(1) is hydrolysed to DHET(1) by EPHX2

Stable Identifier
R-HSA-2161961
Type
Reaction
Species
Homo sapiens
Compartment
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Epoxide hydrolase 2 (EPHX2) hydrolyses 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids ("EET(1)") to their corresponding dihydroxyeicosatrienoic acids ("DHET(1)") (Werner et al. 2002; Gomez et al. 2004). The majority of the EET biological activities are diminished by this hydrolysis.

Literature References
PubMed ID Title Journal Year
15096040 Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis

Gomez, GA, Morisseau, C, Hammock, BD, Christianson, DW

Biochemistry 2004
12468260 Characterization and identification of cytochrome P450 metabolites of arachidonic acid released by human peritoneal macrophages obtained from the pouch of Douglas

Werner, K, Schaefer, WR, Schweer, H, Deppert, WR, Karck, U, Zahradnik, HP

Prostaglandins Leukot Essent Fatty Acids 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
epoxide hydrolase activity of EPHX2 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created