LTA4 is hydrolysed to 6t-/6t,12epi-LTB4

Stable Identifier
R-HSA-2161962
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Non-enzymatic hydrolysis of the leukotriene A4 (LTA4) epoxide bond creates 6-trans leukotriene B4 (6t-LTB4) and 6-trans,12-epi leukotriene B4 (6t,12epi-LTB4) stereoisomers (Mansour & Agha 1999, Sirois et al. 1985).

Literature References
PubMed ID Title Journal Year
10741385 Inhibition of calcium ionophore-stimulated leukotriene generation from intact human neutrophils by captopril

Mansour, M, Agha, A

Res Commun Mol Pathol Pharmacol 1999
2998743 Metabolism of leukotrienes by adult and fetal human lungs

Sirois, P, Brousseau, Y, Chagnon, M, Gentile, J, Gladu, M, Salari, H, Borgeat, P

Exp Lung Res 1985
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