Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15

Stable Identifier
R-HSA-2161964
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Arachidonate 12-lipoxygenase, 12S-type (ALOX12) (Funk et al. 1990, Izumi et al. 1990) and arachidonate 15-lipoxygenase (ALOX15) (Kuhn et al. 1993, Sigal et al. 1990) convert arachidonic acid into 12S-hydroperoxy-eicosatetraenoic acid (12S-HpETE).

Literature References
PubMed ID Title Journal Year
2377602 Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase

Funk, CD, Furci, L, FitzGerald, GA

Proc Natl Acad Sci U S A 1990
8334154 Overexpression, purification and characterization of human recombinant 15-lipoxygenase

Kühn, H, Barnett, J, Grunberger, D, Baecker, P, Chow, J, Nguyen, B, Bursztyn-Pettegrew, H, Chan, H, Sigal, E

Biochim Biophys Acta 1993
2318885 Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related

Sigal, E, Grunberger, D, Highland, E, Gross, C, Dixon, RA, Craik, CS

J Biol Chem 1990
2217179 Cloning of the cDNA for human 12-lipoxygenase

Izumi, T, Hoshiko, S, Rådmark, O, Samuelsson, B

Proc Natl Acad Sci U S A 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
arachidonate 12-lipoxygenase activity of ALOX12/15 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created