LTA4 is converted to EXA4 by ALOX15

Stable Identifier
R-HSA-2162019
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Analogous to arachidonate 5-lipoxygenase (ALOX5) biosynthesis of leukotriene A4 (LTA4), arachidonate 15-lipoxygenase (ALOX15) can form an epoxide across C-14 and C-15 to form 14,15-LTA4 aka eoxin A4 (EXA4) (Feltenmark et al. 2008, Claesson et al. 2008).

Literature References
PubMed ID Title Journal Year
18647347 Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma

Claesson, HE, Griffiths, WJ, Brunnström, A, Schain, F, Andersson, E, Feltenmark, S, Johnson, HA, Porwit, A, Sjöberg, J, Björkholm, M

FEBS J 2008
18184802 Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells

Feltenmark, S, Gautam, N, Brunnström, A, Griffiths, W, Backman, L, Edenius, C, Lindbom, L, Björkholm, M, Claesson, HE

Proc Natl Acad Sci U S A 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
eoxin A4 synthase activity of ALOX15:Fe2+ [cytosol]
Physical Entity
Activity
Orthologous Events
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Created