LTA4 is converted to EXA4 by ALOX15

Stable Identifier
R-HSA-2162019
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Analogous to arachidonate 5-lipoxygenase (ALOX5) biosynthesis of leukotriene A4 (LTA4), arachidonate 15-lipoxygenase (ALOX15) can form an epoxide across C-14 and C-15 to form 14,15-LTA4 aka eoxin A4 (EXA4) (Feltenmark et al. 2008, Claesson et al. 2008).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
eoxin A4 synthase activity of ALOX15:Fe2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed