Reactome: A Curated Pathway Database

LTA4 is converted to EXA4 by ALOX15

Stable Identifier
R-HSA-2162019
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Analogous to arachidonate 5-lipoxygenase (ALOX5) biosynthesis of leukotriene A4 (LTA4), arachidonate 15-lipoxygenase (ALOX15) can form an epoxide across C-14 and C-15 to form 14,15-LTA4 aka eoxin A4 (EXA4) (Feltenmark et al. 2008, Claesson et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
eoxin A4 synthase activity of ALOX15:Fe2+ [cytosol] ALOX15:Fe2+ [cytosol] eoxin A4 synthase activity (0097260)
Orthologous Events