Reactome | COQ3 methylates DHDB

COQ3 methylates DHDB

Stable Identifier

R-HSA-2162193

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

DHDB is methylated to MHDB by COQ3

ReviewStatus

5/5

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Mitochondrial O-methyltransferase COQ3 converts 3,4-dihydroxy-5-decaprenylbenzoic acid (DHDB) to 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid (MHDB) (Jonassen & Clarke 2000). COQ3 is a membrane protein (Zhu et al., 2015).

Literature References

PubMed ID	Title	Journal	Year
26251450	Structural and biochemical studies reveal UbiG/Coq3 as a class of novel membrane-binding proteins Zhang, X, Zhu, Y, Niu, L, Wu, B, Wang, J, Li, X, Fan, X, Teng, M	Biochem J	2015
10777520	Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis Jonassen, T, Clarke, CF	J Biol Chem	2000