Reactome | p-T,Y-MAPK8 [nucleoplasm]

p-T,Y-MAPK8 [nucleoplasm]

Stable Identifier

R-HSA-216349

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-T,Y-JNK1, mitogen-activated protein kinase 8 (phosphorylated)

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Locations in the PathwayBrowser for interactor UniProt:P27986 PIK3R1

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External Reference Information

External Reference

UniProt:P45983 MAPK8

Gene Names

MAPK8, JNK1, PRKM8, SAPK1, SAPK1C

Chain

chain:1-427

Reference Genes

BioGPS Gene:5599 MAPK8

COSMIC (genes):MAPK8 MAPK8

CTD Gene:5599 MAPK8

dbSNP Gene:5599 MAPK8

ENSEMBL:ENSG00000107643 MAPK8

HGNC:6881 MAPK8

KEGG Gene (Homo sapiens):5599 MAPK8

Monarch:5599 MAPK8

NCBI Gene:5599 MAPK8

OMIM:601158 MAPK8

UCSC:P45983 MAPK8

Reference Transcript

Other Identifiers

0003520086

11736292_a_at

11747477_a_at

11759192_a_at

16704687

2070_i_at

2071_s_at

210477_x_at

210671_x_at

226046_at

226048_at

229664_at

3245685

3245686

3245690

3245693

3245701

3245713

3245714

3245715

3245717

3245718

3245720

3245721

3245723

3245724

3245728

3245731

3245732

3245735

3245739

3245740

3245741

3245742

3245743

3245744

34006_s_at

47790_at

49510_at

49512_at

5599

56901_at

7927389

A_14_P128899

A_23_P202540

A_23_P356152

A_24_P286898

A_33_P3250289

GE57700

GO:0000165

GO:0000166

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0004705

GO:0004707

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006259

GO:0006302

GO:0006464

GO:0006468

GO:0006810

GO:0006914

GO:0006950

GO:0006979

GO:0007005

GO:0007165

GO:0007254

GO:0007258

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0009411

GO:0009612

GO:0010628

GO:0015031

GO:0016241

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0019899

GO:0030054

GO:0030234

GO:0030424

GO:0031063

GO:0031281

GO:0031343

GO:0032091

GO:0032880

GO:0034198

GO:0034614

GO:0034641

GO:0035033

GO:0035556

GO:0038095

GO:0042752

GO:0042826

GO:0043065

GO:0043066

GO:0043167

GO:0043226

GO:0045202

GO:0048511

GO:0051090

GO:0051247

GO:0051276

GO:0051403

GO:0061024

GO:0071222

GO:0071260

GO:0071276

GO:0071345

GO:0090045

GO:0097441

GO:0106310

GO:0106311

GO:1900740

GO:1902595

HMNXSV003013434

Hs.267445.0.S1_3p_at

Hs.267445.0.S2_3p_at

Hs.65228.0.A1_3p_at

ILMN_1668627

ILMN_1849941

ILMN_2308806

ILMN_2364574

PH_hs_0026061

PH_hs_0039294

TC10000322.hg

TC10002063.hg

U35005_s_at

g1463136_3p_a_at

g1463136_3p_s_at

Participates

as an output of

as a component of

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)

as an input of

APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)

as a member of

p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MAPK8 [cytosol]

p-T,Y-MAPK8 [cytosol]

Inferred To

phospho-SMK1 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-jnk-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-MAPK8 [nucleoplasm] (Bos taurus)

phospho-MAPK8 [nucleoplasm] (Canis familiaris)

phospho-MAPK8 [nucleoplasm] (Gallus gallus)

phospho-MAPK8 [nucleoplasm] (Sus scrofa)

phospho-bsk [nucleoplasm] (Drosophila melanogaster)

phospho-erkA [nucleoplasm] (Dictyostelium discoideum)

phospho-mapk8 [nucleoplasm] (Danio rerio)

Homologues of p-T,Y-MAPK8 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-T,Y-MAPK8 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-T,Y-MAPK8 [nucleoplasm] (Plasmodium falciparum)

phospho-p-T,Y-MAPK8 [nucleoplasm] (Xenopus tropicalis)

phospho-Mapk8 [nucleoplasm] (Mus musculus)

phospho-Mapk8 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-threonine at unknown position

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001310257.1, NP_001310260.1, NP_001310258.1, NP_001310256.1, NP_001310255.1, NP_001310252.1, NP_620634.1, NP_001265477.1, NP_001310254.1, NP_001310253.1, NP_620637.1, NP_001310259.1, NP_001265476.1, NP_001310251.1, NP_001310231.1, NP_001310250.1

ZINC - World Drugs

MK08_HUMAN

Guide to Pharmacology - Targets

1496

OpenTargets

ENSG00000107643

ZINC - FDA approved

MK08_HUMAN

ZINC - Substances

MK08_HUMAN

ZINC - Biogenic

MK08_HUMAN

ZINC target

P45983

PRO

P45983

PDB

4UX9, 3VUK, 4L7F, 2H96, 2XRW, 3VUI, 2XS0, 3VUG, 3O17, 3VUH, 5LW1, 3O2M, 3VUD, 2NO3, 1UKI, 3V3V, 4HYU, 1UKH, 4HYS, 2G01, 4E73, 2GMX, 4IZY, 6ZR5, 4G1W, 4YR8, 4AWI, 3VUM, 4QTD, 3PZE, 3VUL, 3ELJ, 6F5E

ZINC - Investigational

MK08_HUMAN

GeneCards

P45983

HPA

ENSG00000107643-MAPK8

Ensembl

ENSP00000363291, ENSP00000363294, ENSP00000363297, ENST00000360332, ENSG00000107643, ENST00000374182, ENST00000374189, ENSP00000363304, ENST00000374176, ENSP00000353483, ENST00000395611, ENSP00000378974, ENST00000374179

Pharos - Targets

P45983

ZINC - Predictions - Purchasable

MK08_HUMAN

HMDB Protein

HMDBP01536

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.854	5
UniProt:Q9UQF2 JIP1			0.623	7
UniProt:P27986 PIK3R1	15	PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.623	6
UniProt:P45985 MAP2K4	4	MAP2K4(?-399) [cytosol] (R-HSA-5211396) MAP2K4(1-?) [cytosol] (R-HSA-5211402) p-S257,T261-MAP2K4 [cytosol] (R-HSA-168170) MAP2K4 [cytosol] (R-HSA-168107)	0.59	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q13202 DUSP8	2	DUSP8 [nucleoplasm] (R-HSA-5675349) DUSP8 [cytosol] (R-HSA-5675348)	0.547	2
UniProt:O14733-2 MAP2K7			0.544	3
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.536	2
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.527	2
UniProt:P29401 TKT	1	TKT [cytosol] (R-HSA-71321)	0.527	2
UniProt:P16104 H2AX	7	K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [extracellular region] (R-HSA-977583)	0.524	3
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.516	2
UniProt:Q8N122 RPTOR	3	p-S722,S792-RPTOR [cytosol] (R-HSA-3132767) RPTOR [cytosol] (R-HSA-3006727) RPTOR [nucleoplasm] (R-HSA-5083664)	0.499	6
UniProt:Q9WVI9-1 MAPK8IP1			0.499	2
UniProt:O14733 MAP2K7	4	MAP2K7(?-419) [cytosol] (R-HSA-5211401) MAP2K7(2-?) [cytosol] (R-HSA-5211389) MAP2K7 [cytosol] (R-HSA-450276) p-S271,T275-MAP2K7 [cytosol] (R-HSA-450353)	0.483	4
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.483	2

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