4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane

Stable Identifier
R-HSA-216723
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ABCA1-mediated transport of intracellular cholesterol to the cell surface
ReviewStatus
5/5
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In an ATP-dependent reaction, ATP-binding cassette sub-family A member 1 (ABCA1, ATPA1) mediates the movement of intracellular cholesterol to the extracellular face of the plasma membrane. Cholesterol associated with cytosolic vesicles is a substrate for this reaction. Under physiologocal conditions, the active form of ABCA1 is predominantly a tetramer associated with apolipoprotein A-I (APOA1) (Denis et al. 2004; Vedhachalam et al., 2007). The number of lipid molecules transported per ATP consumed is not known.
Literature References
PubMed ID Title Journal Year
17604270 Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles

Nickel, M, Saito, H, Duong, PT, Phillips, MC, Rothblat, GH, Dhanasekaran, P, Nguyen, D, Lund-Katz, S, Vedhachalam, C

J Biol Chem 2007
Participants
Participates
Catalyst Activity

cholesterol transfer activity of 4xPALM-C-p-2S-ABCA1 tetramer:APOA1 [plasma membrane]

Orthologous Events
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