SMAD7:SMURF2 complex translocates to the cytosol

Stable Identifier
R-HSA-2167876
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After forming a complex in the nucleus, SMAD7:SMURF2 traffics to the cytosol (Kavsak et al. 2000). This was inferred from experiments that used a recombinant mouse Smad7 and recombinant human SMURF2.

Literature References
PubMed ID Title Journal Year
11163210 Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Kavsak, P, Rasmussen, RK, Causing, CG, Bonni, S, Zhu, H, Thomsen, GH, Wrana, JL

Mol Cell 2000
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