MASTL (GWL) phosphorylates ARPP19

Stable Identifier
R-HSA-2168079
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MASTL (GWL i.e. Greatwall kinase) phosphorylates ARPP19 on serine residue S62 (Gharbi-Ayachi et al. 2010). S62 of human ARPP19 corresponds to serine residue S67 of Xenopus Arpp19, which is phosphorylated by Xenopus Mastl (Mochida et al. 2010).

Literature References
PubMed ID Title Journal Year
21164014 The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

Gharbi-Ayachi, A, Labbe, JC, Burgess, A, Vigneron, S, Strub, JM, Brioudes, E, Van-Dorsselaer, A, Castro, A, Lorca, T

Science 2010
21164013 Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis

Mochida, S, Maslen, SL, Skehel, M, Hunt, T

Science 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T194,T207,T741-MASTL [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created