Reactome | MASTL (GWL) phosphorylates ARPP19

MASTL (GWL) phosphorylates ARPP19

Stable Identifier

R-HSA-2168079

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MASTL (GWL i.e. Greatwall kinase) phosphorylates ARPP19 on serine residue S62 (Gharbi-Ayachi et al. 2010). S62 of human ARPP19 corresponds to serine residue S67 of Xenopus Arpp19, which is phosphorylated by Xenopus Mastl (Mochida et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
21164013	Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis Mochida, S, Maslen, SL, Skehel, M, Hunt, T	Science	2010
21164014	The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A Gharbi-Ayachi, A, Labbe, JC, Burgess, A, Vigneron, S, Strub, JM, Brioudes, E, Van-Dorsselaer, A, Castro, A, Lorca, T	Science	2010