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What is Reactome ?
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Table of Contents
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Analyse gene expression
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Go!
HBB [extracellular region]
Stable Identifier
R-HSA-2168872
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Hemoglobin subunit beta, HBB_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
CO binds to free ferrohemoglobin (Homo sapiens)
COHb [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
H2O2 oxidises ferrohemoglobin to MetHb (Homo sapiens)
COHb [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
MetHb [extracellular region] (Homo sapiens)
Hemoglobin beta:ferriheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
H2O2 reduces MetHb (Homo sapiens)
MetHb [extracellular region] (Homo sapiens)
Hemoglobin beta:ferriheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Heme signaling (Homo sapiens)
FeHM dissociates from MetHb (Homo sapiens)
ApoHb [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
MetHb [extracellular region] (Homo sapiens)
Hemoglobin beta:ferriheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
H2O2 oxidises ferrohemoglobin to MetHb (Homo sapiens)
COHb [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
MetHb [extracellular region] (Homo sapiens)
Hemoglobin beta:ferriheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Exocytosis of tertiary granule lumen proteins (Homo sapiens)
Tertiary granule lumen proteins [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenging of heme from plasma (Homo sapiens)
Ferriheme is transferred from Methemoglobin to Hemopexin (Homo sapiens)
ApoHb [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
MetHb [extracellular region] (Homo sapiens)
Hemoglobin beta:ferriheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Haptoglobin binds Hemoglobin (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Hemoglobin:Haptoglobin [extracellular region] (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Haptoglobin-related Protein binds Hemoglobin (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Hemoglobin:HPR:APOL1:APOA1:HDL3 [extracellular region] (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Haptoglobin:Hemoglobin binds CD163 (Homo sapiens)
Hemoglobin:Haptoglobin [extracellular region] (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Hemoglobin:Haptoglobin:CD163 [plasma membrane] (Homo sapiens)
Hemoglobin:Haptoglobin [extracellular region] (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Hemoglobin:Haptoglobin:CD163 is endocytosed (Homo sapiens)
Hemoglobin:Haptoglobin:CD163 [plasma membrane] (Homo sapiens)
Hemoglobin:Haptoglobin [extracellular region] (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Homo sapiens)
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
HBB [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68871 HBB
Gene Names
HBB
Chain
initiator methionine:1, chain:2-147, peptide:33-42, peptide:33-39
Reference Genes
BioGPS Gene:3043 HBB
COSMIC (genes):HBB HBB
CTD Gene:3043 HBB
dbSNP Gene:3043 HBB
ENSEMBL:ENSG00000244734 HBB
ENSEMBL:ENSG00000244734.4 HBB
HGNC:4827 HBB
KEGG Gene (Homo sapiens):3043 HBB
Monarch:3043 HBB
NCBI Gene:3043 HBB
OMIM:141900 HBB
UCSC:P68871 HBB
Reference Transcript
RefSeq:NM_000518.4 HBB
Other Identifiers
11715347_s_at
11715348_x_at
11753712_x_at
209116_PM_x_at
209116_x_at
211696_PM_x_at
211696_x_at
217232_PM_x_at
217232_x_at
3043
31687_f_at
32052_at
3360403
3360404
3360405
3360408
3360409
3360410
3360411
3360413
3360414
3360422
7946033
A_23_P203558
GE61327
GO:0003013
GO:0003014
GO:0003824
GO:0004601
GO:0005344
GO:0005515
GO:0005576
GO:0005615
GO:0005829
GO:0005833
GO:0007155
GO:0008217
GO:0010942
GO:0015670
GO:0015671
GO:0016209
GO:0016491
GO:0019825
GO:0020037
GO:0030185
GO:0030492
GO:0031410
GO:0031720
GO:0031721
GO:0031838
GO:0042060
GO:0042542
GO:0042744
GO:0043177
GO:0043226
GO:0045429
GO:0046872
GO:0070062
GO:0070293
GO:0070527
GO:0071682
GO:0072562
GO:0097746
GO:0098754
GO:0098869
GO:0140104
GO:1904724
GO:1904813
HMNXSV003017647
Hs.155376.1.A1_3p_s_at
ILMN_2100437
M25079_s_at
PH_hs_0029250
PH_hs_0031887
TC11001330.hg
TC11003023.hg
g13549111_3p_at
g179408_3p_s_at
Participates
as a component of
Hemoglobin beta:ferroheme b [extracellular region] (Homo sapiens)
ApoHb [extracellular region] (Homo sapiens)
Hemoglobin beta:ferriheme b [extracellular region] (Homo sapiens)
as a member of
Tertiary granule lumen proteins [extracellular region] (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
CO-H+-HBB [cytosol]
HBB [endocytic vesicle lumen]
HBB [tertiary granule lumen]
HBB [ficolin-1-rich granule lumen]
HBB [late endosome lumen]
HBB [cytosol]
HBB [lysosomal lumen]
Inferred To
HBB [extracellular region]
(Bos taurus)
HBB [extracellular region]
(Canis familiaris)
HBB [extracellular region]
(Danio rerio)
HBB [extracellular region]
(Gallus gallus)
HBB [extracellular region]
(Mus musculus)
HBB [extracellular region]
(Rattus norvegicus)
HBB [extracellular region]
(Sus scrofa)
HBB [extracellular region]
(Xenopus tropicalis)
Homologues of HBB [extracellular region]
(Danio rerio)
Homologues of HBB [extracellular region]
(Gallus gallus)
Homologues of HBB [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000509.1
OpenTargets
ENSG00000244734
HPA
ENSG00000244734-HBB
GeneCards
P68871
Ensembl
ENSP00000494175
,
ENST00000335295
,
ENST00000647020
,
ENSG00000244734
,
ENSP00000333994
PRO
P68871
Pharos - Targets
P68871
Orphanet
16186
HMDB Protein
HMDBP01625
PDB
5KSJ
,
1THB
,
1J7W
,
7XGY
,
1GBV
,
2HBD
,
1Y7Z
,
6KAT
,
1NIH
,
2H35
,
1CH4
,
1YGD
,
1A01
,
1LFY
,
5KDQ
,
1XYE
,
2HCO
,
3HHB
,
7CUE
,
3QJC
,
4MQI
,
6HK2
,
1A3O
,
1O1N
,
5JDO
,
6HBW
,
1LFZ
,
1C7C
,
1HGC
,
1MKO
,
1R1X
,
1QXD
,
4XS0
,
6TB2
,
1YDZ
,
1DKE
,
7JXZ
,
4HHB
,
1Y4Q
,
1Y8W
,
1YHR
,
6NBD
,
4N8T
,
4N7P
,
7UD7
,
1B86
,
1XZ7
,
1XZV
,
7AEV
,
5E29
,
1Y46
,
7PCQ
,
1LFL
,
1CBL
,
1YEO
,
1JY7
,
6BWU
,
1YH9
,
2W6V
,
7K4M
,
1QI8
,
1YZI
,
7UF6
,
1YG5
,
6XDT
,
3OO4
,
1Y2Z
,
6L5X
,
1O1M
,
1Y7D
,
1CLS
,
2HBS
,
1VWT
,
6KYE
,
4IJ2
,
4MQG
,
6KAU
,
1A0U
,
1RQ4
,
1DXV
,
1KD2
,
6KAP
,
1Y0D
,
5SW7
,
2HHD
,
5X2T
,
4N7O
,
6FQF
,
7JY3
,
4ROL
,
3B75
,
2HBE
,
6KAR
,
3S66
,
1HGB
,
1XZ5
,
6LCX
,
1Y45
,
5X2R
,
1COH
,
1YEN
,
6BB5
,
2DN3
,
7AET
,
3HXN
,
1BZ1
,
3P5Q
,
1HBB
,
1SDL
,
1BAB
,
7PCF
,
6L5W
,
1LFV
,
1XXT
,
1YFF
,
1ABW
,
1XY0
,
2DXM
,
3IC0
,
1HCO
,
1Y0C
,
1HAC
,
1Y0A
,
2DN1
,
1QSH
,
3W4U
,
1YVQ
,
1RVW
,
1YIE
,
4M4B
,
1M9P
,
5U3I
,
4NI1
,
1Y22
,
1Y85
,
6KAH
,
6KAV
,
3QJD
,
1AJ9
,
1J7S
,
7JY0
,
4L7Y
,
1O1K
,
6NQ5
,
1O1I
,
3KMF
,
7UD8
,
1NEJ
,
5NI1
,
2HBC
,
1LJW
,
6L5V
,
4X0L
,
1O1L
,
3OO5
,
1GBU
,
1YGF
,
1A0Z
,
5WOG
,
1Y7C
,
5EE4
,
1HGA
,
1Y4P
,
1QSI
,
1Y5K
,
5KSI
,
1RQ3
,
1ABY
,
5UFJ
,
1G9V
,
3NL7
,
3WHM
,
1YE2
,
2YRS
,
1Y4V
,
6HAL
,
6DI4
,
1NQP
,
1C7B
,
1BUW
,
1O1J
,
1O1P
,
7AEU
,
1K1K
,
7DY3
,
1YEV
,
1XZ4
,
2W72
,
1IRD
,
8EGI
,
1YIH
,
1J41
,
1LFT
,
5WOH
,
8DOV
,
1J3Y
,
1XZ2
,
4M4A
,
1YEU
,
1Y09
,
3R5I
,
7VDE
,
6KA9
,
6BNR
,
6NBC
,
5E83
,
3D7O
,
4FC3
,
6KAO
,
5X2U
,
1GZX
,
1SDK
,
1Y35
,
6XD9
,
1Y5J
,
1J40
,
3ODQ
,
1Y4G
,
7UF7
,
1RPS
,
6XE7
,
1CMY
,
7JY1
,
6BWP
,
1BZZ
,
1CBM
,
1YVT
,
4MQC
,
1DXU
,
1C7D
,
4N7N
,
1FN3
,
1Y83
,
1HBA
,
3WCP
,
7JJQ
,
5URC
,
5HU6
,
1J3Z
,
6KAS
,
5HY8
,
3QJB
,
1J7Y
,
1A00
,
2M6Z
,
4MQH
,
1Y0W
,
1O1O
,
5X2S
,
1HBS
,
7DY4
,
2HHE
,
1R1Y
,
1BZ0
,
3IC2
,
1A3N
,
2HBF
,
4ROM
,
1YE1
,
6KAQ
,
2DN2
,
1UIW
,
3D17
,
1BBB
,
3QJE
,
3ONZ
,
1XZU
,
5UCU
,
6L5Y
,
1Y4F
,
7PCH
,
1HHO
,
1YE0
,
2HHB
,
3DUT
,
1HAB
,
6KAE
,
1Y4B
,
1GLI
,
1K0Y
,
1YEQ
,
4WJG
,
1Y0T
,
1BIJ
,
4NI0
,
2D5Z
,
3SZK
,
1RQA
,
1DXT
,
5E6E
,
3S65
,
2D60
,
1YHE
,
6KAI
,
3NMM
,
1QXE
,
5VMM
,
1LFQ
,
1Y31
,
1Y7G
,
1Y4R
,
6LCW
,
1HDB
,
1Y5F
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P69905 HBA1
4
CO-H+-HBA1 [cytosol]
(R-HSA-1237026)
HBA1 [cytosol]
(R-HSA-1008268)
HBA1 [endocytic vesicle lumen]
(R-HSA-2230966)
HBA1 [extracellular region]
(R-HSA-2168862)
0.967
29
UniProt:P02008 HBAZ
0.857
7
UniProt:Q6B0K9 HBM
0.556
3
UniProt:P09105 HBAT
0.556
3
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