Reactome | Hemopexin binds Hemes

Hemopexin binds Hemes

Stable Identifier

R-HSA-2168886

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Hemopexin binds either ferriheme b or ferroheme b, however the stability of the complex containing ferriheme b is greater than the stability of the complex containing ferroheme b (Morgan 1976, Pasternack et al. 1983, Solar et al. 1989, Miller and Shaklai 1999, Rosell et al. 2005, Mauk and Mauk 2010).

Literature References

PubMed ID	Title	Journal	Year
20430887	Metal ions and electrolytes regulate the dissociation of heme from human hemopexin at physiological pH Mauk, MR, Mauk, AG	J Biol Chem	2010
6849882	Hemin binding to serum proteins and the catalysis of interprotein transfer Pasternack, RF, Gibbs, EJ, Hoeflin, E, Kosar, WP, Kubera, G, Skowronek, CA, Wong, NM, Muller-Eberhard, U	Biochemistry	1983
10381560	Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation Miller, YI, Shaklai, N	Biochim Biophys Acta	1999
1008494	The binding and transport of heme by hemopexin Morgan, WT	Ann Clin Res	1976
2806549	Serum proteins as mediators of hemin efflux from red cell membranes: specificity of hemopexin Solar, I, Muller-Eberhard, U, Shaklai, N	FEBS Lett	1989
15697213	pH- and metal ion-linked stability of the hemopexin-heme complex Rosell, FI, Mauk, MR, Mauk, AG	Biochemistry	2005