Ferriheme is transferred from Albumin to Hemopexin

Stable Identifier
R-HSA-2168887
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Despite the lower affinity of ferriheme for albumin than for hemopexin, ferriheme initially associates with albumin, presumably because the molar concentration of albumin in plasma is considerably greater than that of hemopexin. Ferriheme is transferred directly from serum albumin to hemopexin (Morgan et al. 1976, Pasternack et al. 1983, Pasternack et al. 1985).

Literature References
PubMed ID Title Journal Year
4074707 Kinetics of hemoprotein reduction and interprotein heme transfer

Pasternack, RF, Gibbs, EJ, Mauk, AG, Reid, LS, Wong, NM, Kurokawa, K, Hashim, M, Muller-Eberhard, U

Biochemistry 1985
6849882 Hemin binding to serum proteins and the catalysis of interprotein transfer

Pasternack, RF, Gibbs, EJ, Hoeflin, E, Kosar, WP, Kubera, G, Skowronek, CA, Wong, NM, Muller-Eberhard, U

Biochemistry 1983
971416 Transfer of heme from heme-albumin to hemopexin

Morgan, WT, Liem, HH, Sutor, RP, Muller-Ebergard, U

Biochim Biophys Acta 1976
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