Ferriheme is transferred from Albumin to Hemopexin

Stable Identifier
R-HSA-2168887
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Ferriheme is transferred from Albumin to Hemopexin
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Despite the lower affinity of ferriheme for albumin than for hemopexin, ferriheme initially associates with albumin, presumably because the molar concentration of albumin in plasma is considerably greater than that of hemopexin. Ferriheme is transferred directly from serum albumin to hemopexin (Morgan et al. 1976, Pasternack et al. 1983, Pasternack et al. 1985).
Literature References
PubMed ID Title Journal Year
6849882 Hemin binding to serum proteins and the catalysis of interprotein transfer

Pasternack, RF, Gibbs, EJ, Hoeflin, E, Kosar, WP, Kubera, G, Skowronek, CA, Wong, NM, Muller-Eberhard, U

Biochemistry 1983
4074707 Kinetics of hemoprotein reduction and interprotein heme transfer

Pasternack, RF, Gibbs, EJ, Mauk, AG, Reid, LS, Wong, NM, Kurokawa, K, Hashim, M, Muller-Eberhard, U

Biochemistry 1985
971416 Transfer of heme from heme-albumin to hemopexin

Morgan, WT, Liem, HH, Sutor, RP, Muller-Ebergard, U

Biochim Biophys Acta 1976
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Orthologous Events
Ferriheme is transferred from Albumin to Hemopexin (Bos taurus)
Ferriheme is transferred from Albumin to Hemopexin (Mus musculus)
Ferriheme is transferred from Albumin to Hemopexin (Rattus norvegicus)
Ferriheme is transferred from Albumin to Hemopexin (Sus scrofa)
Authored
May, B  (2012-03-21)
Reviewed
Tolosano, E  (2013-02-13)
Fiorito, V  (2013-02-13)
Moestrup, SK  (2013-02-18)
Created
May, B  (2012-03-25)
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