Alpha1-Microglobulin binds heme

Stable Identifier
R-HSA-2168888
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Alpha1-Microglobulin binds heme
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Alpha-1-Microglobulin binds heme b (Allhorn et al. 2002, Larsson et al. 2004). The crystal structure of the complex indicates that each microglobulin molecule binds 2 heme molecules and the microglobulin:heme complex trimerizes (Siebel et al. 2012).
Literature References
PubMed ID Title Journal Year
15542058 The lipocalin alpha(1)-microglobulin binds heme in different species

Larsson, J, Kerström, B, Allhorn, M

Arch Biochem Biophys 2004
22492620 Insertion of heme b into the structure of the Cys34-carbamidomethylated human lipocalin ?(1)-microglobulin: formation of a [(heme)(2) (?(1)-Microglobulin)](3) complex

Siebel, JF, Åkerström, B, Kosinsky, RL, Knipp, M

Chembiochem 2012
11877257 Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties

Allhorn, M, Berggård, T, Nordberg, J, Olsson, ML, Akerström, B

Blood 2002
Participants
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Output
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as an event of
Orthologous Events
Alpha1-Microglobulin binds heme (Canis familiaris)
Alpha1-Microglobulin binds heme (Danio rerio)
Alpha1-Microglobulin binds heme (Gallus gallus)
Alpha1-Microglobulin binds heme (Mus musculus)
Alpha1-Microglobulin binds heme (Rattus norvegicus)
Alpha1-Microglobulin binds heme (Sus scrofa)
Alpha1-Microglobulin binds heme (Xenopus tropicalis)
Authored
May, B  (2012-03-21)
Reviewed
Tolosano, E  (2013-02-13)
Moestrup, SK  (2013-02-18)
Fiorito, V  (2013-02-13)
Created
May, B  (2012-03-25)
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