Reactome | RAD51C [nucleoplasm]

RAD51C [nucleoplasm]

Stable Identifier

R-HSA-217039

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA repair protein RAD51 homolog 3, (R51H3) (RAD51-like protein 2)

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        D-loop extension by DNA polymerases (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        CX3 complex binds D-loop structures (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        CX3 complex formation (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        BCDX2 complex formation (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex stabilizes RAD51 filament (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        BLM mediates dissolution of double Holliday junction (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
        
        D-loop dissociation and strand annealing (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43502 RAD51C

Gene Names

RAD51C, RAD51L2

Chain

chain:1-376

Reference Genes

BioGPS Gene:5889 RAD51C

COSMIC (genes):RAD51C RAD51C

CTD Gene:5889 RAD51C

dbSNP Gene:5889 RAD51C

ENSEMBL:ENSG00000108384 RAD51C

HGNC:9820 RAD51C

KEGG Gene (Homo sapiens):5889 RAD51C

Monarch:5889 RAD51C

NCBI Gene:5889 RAD51C

OMIM:602774 RAD51C

UCSC:O43502 RAD51C

Reference Transcript

Other Identifiers

0001170239

0005720575

0006520131

11724062_a_at

11732520_a_at

11750293_a_at

16836457

206066_s_at

209849_s_at

3728777

3728778

3728779

3728786

3728787

3728788

3728789

3728793

3728798

3728802

3728805

3728810

3728813

3728814

3728815

3728817

41479_s_at

41480_at

43342_i_at

43343_r_at

5889

8008754

A_14_P128689

A_23_P207014

A_32_P24359

GO:0000003

GO:0000166

GO:0000278

GO:0000400

GO:0000722

GO:0000724

GO:0003674

GO:0003677

GO:0004518

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0006259

GO:0006281

GO:0006310

GO:0006950

GO:0006974

GO:0007049

GO:0007059

GO:0007062

GO:0007066

GO:0007131

GO:0007141

GO:0007283

GO:0007596

GO:0008094

GO:0008150

GO:0008821

GO:0010971

GO:0016887

GO:0030054

GO:0032991

GO:0033063

GO:0033065

GO:0034641

GO:0042592

GO:0043167

GO:0043226

GO:0043231

GO:0048471

GO:0048476

GO:0051276

ILMN_1667644

ILMN_1695386

ILMN_1760635

PH_hs_0019562

g2909800_3p_a_at

g4506390_3p_a_at

Participant Of

hasComponent

input

This entity regulates

Positively

Formation of meiotic single-stranded DNA invasion complex

Inferred To

rad51c [nucleoplasm] (Danio rerio)

rad51c [nucleoplasm] (Dictyostelium discoideum)

rad51c [nucleoplasm] (Xenopus tropicalis)

RAD51C [nucleoplasm] (Bos taurus)

RAD51C [nucleoplasm] (Canis familiaris)

RAD51C [nucleoplasm] (Gallus gallus)

RAD51C [nucleoplasm] (Sus scrofa)

rhp55 [nucleoplasm] (Schizosaccharomyces pombe)

RAD55 [nucleoplasm] (Saccharomyces cerevisiae)

Rad51c [nucleoplasm] (Mus musculus)

Rad51c [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_002867.1, NP_478123.1

OpenTargets

ENSG00000108384

HPA

ENSG00000108384-RAD51C

GeneCards

O43502

Ensembl

ENST00000337432, ENSP00000336701, ENSG00000108384, ENST00000421782, ENSP00000391450

PRO

O43502

Orphanet

19136

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43542 XRCC3	1	XRCC3 [nucleoplasm] (R-HSA-5685303)	0.934	11
UniProt:O15315 RAD51B	1	RAD51B [nucleoplasm] (R-HSA-983271)	0.871	12
UniProt:O75771 RAD51D	1	RAD51D [nucleoplasm] (R-HSA-216920)	0.767	6
UniProt:O43543 XRCC2	1	XRCC2 [nucleoplasm] (R-HSA-5685302)	0.669	3
UniProt:Q06609 RAD51	2	p-T309-RAD51 [nucleoplasm] (R-HSA-5685231) RAD51 [nucleoplasm] (R-HSA-62637)	0.662	6
UniProt:Q86YC2 PALB2	1	PALB2 [nucleoplasm] (R-HSA-419548)	0.612	10
UniProt:P51587 BRCA2	2	BRCA2 [nucleoplasm] (R-HSA-50951) p-T3387-BRCA2 [nucleoplasm] (R-HSA-5685241)	0.532	5
UniProt:Q6NVH7 SWAP1			0.524	2
UniProt:Q8TDG4 HELQ			0.499	6

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