Reactome | RAD51C [nucleoplasm]

RAD51C [nucleoplasm]

Stable Identifier

R-HSA-217039

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA repair protein RAD51 homolog 3, (R51H3) (RAD51-like protein 2)

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        D-loop extension by DNA polymerases (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        CX3 complex binds D-loop structures (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        CX3 complex formation (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        BCDX2 complex formation (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex stabilizes RAD51 filament (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        BLM mediates dissolution of double Holliday junction (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        FIGNL1 binds RAD51 (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
        
        D-loop dissociation and strand annealing (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        CX3 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        RAD51C [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43502 RAD51C

Gene Names

RAD51C, RAD51L2

Chain

chain:1-376

Reference Genes

BioGPS Gene:5889 RAD51C

COSMIC (genes):RAD51C RAD51C

CTD Gene:5889 RAD51C

dbSNP Gene:5889 RAD51C

ENSEMBL:ENSG00000108384 RAD51C

HGNC:9820 RAD51C

KEGG:hsa:5889 RAD51C

Monarch:5889 RAD51C

NCBI Gene:5889 RAD51C

OMIM:602774 RAD51C

UCSC:O43502 RAD51C

Reference Transcript

Other Identifiers

11724062_a_at

11732520_a_at

11750293_a_at

11761884_at

16836457

206066_PM_s_at

206066_s_at

209849_PM_s_at

209849_s_at

3728777

3728778

3728779

3728780

3728781

3728782

3728783

3728784

3728785

3728786

3728787

3728788

3728789

3728790

3728791

3728792

3728793

3728794

3728795

3728796

3728797

3728798

3728802

3728803

3728804

3728805

3728806

3728807

3728809

3728810

3728811

3728812

3728813

3728814

3728815

3728817

41479_s_at

41480_at

43342_i_at

43343_r_at

5889

71553_at

8008754

81331_at

A_14_P121574

A_14_P128689

A_23_P207014

A_32_P24359

GO:0000166

GO:0000400

GO:0000707

GO:0000722

GO:0000724

GO:0003677

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005657

GO:0005737

GO:0005739

GO:0005829

GO:0006259

GO:0006281

GO:0006310

GO:0007062

GO:0007066

GO:0007131

GO:0007141

GO:0007283

GO:0008821

GO:0010971

GO:0016787

GO:0022414

GO:0030054

GO:0032200

GO:0033063

GO:0033065

GO:0043226

GO:0043231

GO:0048471

GO:0065003

GO:0140013

GO:0140097

GO:0140299

GO:0140657

GO:0140664

HMNXSV003040725

ILMN_1667644

ILMN_1695386

ILMN_1760635

ILMN_2238928

PH_hs_0019562

TC17000714.hg

g2909800_3p_a_at

g4506390_3p_a_at

Participates

as a component of

as an input of

This entity regulates

Positively

Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)

Inferred To

rad51c [nucleoplasm] (Danio rerio)

rad51c [nucleoplasm] (Xenopus tropicalis)

RAD51C [nucleoplasm] (Bos taurus)

RAD51C [nucleoplasm] (Canis familiaris)

RAD51C [nucleoplasm] (Dictyostelium discoideum)

RAD51C [nucleoplasm] (Gallus gallus)

RAD51C [nucleoplasm] (Mus musculus)

RAD51C [nucleoplasm] (Plasmodium falciparum)

RAD51C [nucleoplasm] (Saccharomyces cerevisiae)

RAD51C [nucleoplasm] (Schizosaccharomyces pombe)

RAD51C [nucleoplasm] (Sus scrofa)

Rad51c [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_002867.1, NP_478123.1

ENSEMBL

ENSP00000391450, ENST00000421782, ENST00000337432, ENSP00000336701

OpenTargets

ENSG00000108384

HPA

ENSG00000108384-RAD51C

PRO

O43502

Pharos - Targets

O43502

GlyGen

O43502

Orphanet

RAD51C

PDB

8OUY, 8GBJ, 8OUZ, 8FAZ

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15315 RAD51B	1	RAD51B [nucleoplasm] (R-HSA-983271)	0.94	16
UniProt:O43542 XRCC3	1	XRCC3 [nucleoplasm] (R-HSA-5685303)	0.94	12
UniProt:O75771 RAD51D	1	RAD51D [nucleoplasm] (R-HSA-216920)	0.818	8
UniProt:O43543 XRCC2	1	XRCC2 [nucleoplasm] (R-HSA-5685302)	0.744	4
UniProt:Q06609 RAD51	2	RAD51 [nucleoplasm] (R-HSA-62637) p-T309-RAD51 [nucleoplasm] (R-HSA-5685231)	0.662	6
UniProt:Q86YC2 PALB2	20	PALB2 Y28C [nucleoplasm] (R-HSA-9724169) PALB2 L35P [nucleoplasm] (R-HSA-9724168) PALB2 L24S [nucleoplasm] (R-HSA-9724172) PALB2 L21A [nucleoplasm] (R-HSA-9704339) PALB2 R37H [nucleoplasm] (R-HSA-9724178) PALB2 L21F [nucleoplasm] (R-HSA-9704347) PALB2 E12* [nucleoplasm] (R-HSA-9704349) PALB2 R37C [nucleoplasm] (R-HSA-9724188) PALB2 L35F [nucleoplasm] (R-HSA-9704338) PALB2 L947F [nucleoplasm] (R-HSA-9724554) PALB2 G1043D [nucleoplasm] (R-HSA-9724584) PALB2 T1030I [nucleoplasm] (R-HSA-9704424) PALB2 T841Qfs10 [nucleoplasm] (R-HSA-9704749) PALB2 L1119P [nucleoplasm] (R-HSA-9724589) PALB2 L947S [nucleoplasm] (R-HSA-9724557) PALB2 L1143P [nucleoplasm] (R-HSA-9704428) PALB2 L1070P [nucleoplasm] (R-HSA-9724556) PALB2 C77Vfs100 [nucleoplasm] (R-HSA-9704738) PALB2 L939W [nucleoplasm] (R-HSA-9704417) PALB2 L961P [nucleoplasm] (R-HSA-9724583)	0.612	10
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.532	5
UniProt:Q6JEL2 KLH10			0.527	2
UniProt:Q9UK85 DKKL1			0.527	3
UniProt:Q8TBP5 F174A			0.527	2
UniProt:Q9HBV2 SACA1			0.527	2
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.527	2
UniProt:Q15768 EFNB3	2	p-Y318,Y323,Y337-EFNB3 [plasma membrane] (R-HSA-3928388) EFNB3 [plasma membrane] (R-HSA-2682319)	0.527	2
UniProt:Q6NVH7 SWAP1			0.524	2
UniProt:Q8TDG4 HELQ			0.499	6

Cite Us!