Reactome | DAP12 interactions

DAP12 interactions

Stable Identifier

R-HSA-2172127

DOI

10.3180/REACT_147694.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cells. It mediates signalling for multiple cell-surface receptors expressed by these cells, associating with receptor chains through complementary charged transmembrane amino acids that form a salt-bridge in the context of the hydrophobic lipid bilayer (Lanier et al. 1998). DAP12 homodimers associate with a variety of receptors expressed by macrophages, monocytes and myeloid cells including TREM2, Siglec H and SIRP-beta, as well as activating KIR, LY49 and the NKG2C proteins expressed by NK cells. DAP12 is expressed at the cell surface, with most of the protein lying on the cytoplasmic side of the membrane (Turnbull & Colonna 2007, Tessarz & Cerwenka 2008).

Literature References

PubMed ID	Title	Journal	Year
9490415	Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells Lanier, LL, Corliss, BC, Wu, J, Leong, C, Phillips, JH	Nature	1998
15884055	KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions Tomasello, E, Vivier, E	Eur J Immunol	2005
17220916	Activating and inhibitory functions of DAP12 Turnbull, IR, Colonna, M	Nat. Rev. Immunol.	2007
19120482	DAP10- and DAP12-associated receptors in innate immunity Lanier, LL	Immunol. Rev.	2009
18192027	The TREM-1/DAP12 pathway Tessarz, AS, Cerwenka, A	Immunol Lett	2008