DAP12 interactions

Stable Identifier
R-HSA-2172127
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cells. It mediates signalling for multiple cell-surface receptors expressed by these cells, associating with receptor chains through complementary charged transmembrane amino acids that form a salt-bridge in the context of the hydrophobic lipid bilayer (Lanier et al. 1998). DAP12 homodimers associate with a variety of receptors expressed by macrophages, monocytes and myeloid cells including TREM2, Siglec H and SIRP-beta, as well as activating KIR, LY49 and the NKG2C proteins expressed by NK cells. DAP12 is expressed at the cell surface, with most of the protein lying on the cytoplasmic side of the membrane (Turnbull & Colonna 2007, Tessarz & Cerwenka 2008).

Literature References
PubMed ID Title Journal Year
15884055 KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions

Tomasello, E, Vivier, E

Eur J Immunol 2005
9490415 Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

Lanier, LL, Corliss, BC, Wu, J, Leong, C, Phillips, JH

Nature 1998
17220916 Activating and inhibitory functions of DAP12

Turnbull, IR, Colonna, M

Nat. Rev. Immunol. 2007
19120482 DAP10- and DAP12-associated receptors in innate immunity

Lanier, LL

Immunol. Rev. 2009
18192027 The TREM-1/DAP12 pathway

Tessarz, AS, Cerwenka, A

Immunol Lett 2008
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