Collagen type XIX degradation

Stable Identifier
R-HSA-2172433
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Collagen type XIX is a FACIT (fibril-associated collagens with interrupted triple helix) collagen family member (Inoguchi et al. 1995) with a large non-collagenous N terminal domain that can self-assemble into higher order structures that are stabilized by intermolecular disulfide cross-links. Collagen type XIX is the least abundant collagen so far purified, comprising ?10-6% of dry weight in human umbilical cord (Myers et al. 2003). It is found in the basement membrane (BM) of normal human tissues. In developing embryos it is transiently expressed in certain muscular tissues and brain areas. Due to this localized expression, it is thought to be involved in the formation of specialized BM zones (Sumiyoshi et al. 2001). Collagen XIX is lost early in the development of invasive tumours, prior to penetration and eventual dissolution of the epithelial BM (Amenta et al. 2003). The NC1 domain of type XIX collagen exerts antitumor activity (Ramont et al. 2007).

Literature References
PubMed ID Title Journal Year
12579531 Loss of types XV and XIX collagen precedes basement membrane invasion in ductal carcinoma of the female breast

Amenta, PS, Hadad, S, Lee, MT, Barnard, N, Li, D, Myers, JC

J Pathol 2003
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