FMO1:FAD N-oxidises TAM

Stable Identifier
R-HSA-217255
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
FMO1 N-oxidizes the anti-cancer drug tamoxifen
ReviewStatus
5/5
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Tamoxifen (TAM) is an antiestrogen and currently used extensively for breast cancer therapy. FMOs, especially FMO1 can N-oxidze TAM to tamoxifen N-oxide (TNO). TNO can be reduced back to TAM by the P450 system. TNO appears to be just as potent as TAM but with fewer side-effects so this metabolic cycling could play a part in the use of TNO in the treatment of breast cancer.
Participants
Participates
Catalyst Activity

N,N-dimethylaniline monooxygenase activity of FMO1:FAD [endoplasmic reticulum membrane]

Orthologous Events
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