FMO2:FAD:Mg2+ S-oxidises MTZ

Stable Identifier
R-HSA-217258
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
FMO2 S-oxidizes the antithyroid drug methimazole
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Methimazole is a drug used to treat hyperthyroidism, a condition arising when the thyroid gland is producing too much thyroid hormone. FMO2 is able to the S-oxidized form of methimazole.

Literature References
PubMed ID Title Journal Year
11744609 Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein

Krueger, SK, Martin, SR, Yueh, MF, Pereira, CB, Williams, DE

Drug Metab Dispos 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of FMO2:FAD:Mg2+ [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!