PHF8 demethylates histone H4K20me1

Stable Identifier
R-HSA-2172678
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PHF8, a PHD and Jumonji C domain-containing protein, is recruited to chromatin by binding to dimethylated or trimethylated histone H3 - H3K4me2 and/or H3K4me3. PHF8 demethylates monomethylated histone H4, H4K20me1, a docking site for the condesin II complex (Liu et al. 2010).

Literature References
PubMed ID Title Journal Year
20622854 PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

Liu, W, Tanasa, B, Tyurina, OV, Zhou, TY, Gassmann, R, Liu, WT, Ohgi, KA, Benner, C, Garcia-Bassets, I, Aggarwal, AK, Desai, A, Dorrestein, PC, Glass, CK, Rosenfeld, MG

Nature 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone demethylase activity (H4-K20 specific) of PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created