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USP15 [cytosol]
Stable Identifier
R-HSA-2173138
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ubiquitin carboxyl-terminal hydrolase 15
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
USP15 [cytosol] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
USP15 [cytosol] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
USP15 [cytosol] (Homo sapiens)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Homo sapiens)
USP15 [cytosol] (Homo sapiens)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
USP15 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
USP15 [cytosol] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
USP15 [cytosol] (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
USP15 [cytosol] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
USP15 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y4E8 USP15
Gene Names
USP15, KIAA0529
Chain
initiator methionine:1, chain:2-981
Reference Genes
COSMIC (genes):USP15 USP15
dbSNP Gene:9958 USP15
ENSEMBL:ENSG00000135655 USP15
Participates
as a component of
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Homo sapiens)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
as a member of
UCHL5/USP15 [cytosol] (Homo sapiens)
Inferred To
usp-4 [cytosol]
(Caenorhabditis elegans)
USP15 [cytosol]
(Bos taurus)
USP15 [cytosol]
(Caenorhabditis elegans)
USP15 [cytosol]
(Canis familiaris)
USP15 [cytosol]
(Gallus gallus)
USP15 [cytosol]
(Sus scrofa)
Homologues of USP15 [cytosol]
(Caenorhabditis elegans)
Usp15 [cytosol]
(Mus musculus)
Usp15 [cytosol]
(Rattus norvegicus)
Ghost homologue of USP15 [cytosol]
(Danio rerio)
Ghost homologue of USP15 [cytosol]
(Drosophila melanogaster)
usp15 [cytosol]
(Xenopus tropicalis)
usp-50 [cytosol]
(Caenorhabditis elegans)
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86TM6 SYVN1
1
SYVN1(1-617) [endoplasmic reticulum membrane]
(R-HSA-535496)
0.668
8
UniProt:Q9H257 CARD9
3
CARD9 [cytosol]
(R-HSA-561194)
p-T231-CARD9 [plasma membrane]
(R-HSA-5607623)
CARD9 [plasma membrane]
(R-HSA-5607662)
0.666
4
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.556
3
UniProt:P19474 TRIM21
1
TRIM21 [cytosol]
(R-HSA-976051)
0.556
3
UniProt:P60896 SEM1
2
SEM1 [cytosol]
(R-HSA-8866674)
SEM1 [nucleoplasm]
(R-HSA-8866665)
0.527
2
UniProt:P53350 PLK1
4
PLK1 [cytosol]
(R-HSA-164603)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
PLK1 [nucleoplasm]
(R-HSA-156720)
0.508
2
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