Reactome | USP15 [cytosol]

USP15 [cytosol]

Stable Identifier

R-HSA-2173138

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase 15

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y4E8 USP25

Gene Names

USP25, USP15, KIAA0529

Chain

initiator methionine:, chain:2-981

Reference Genes

BioGPS Gene:9958 USP25

COSMIC (genes):USP25 USP25

CTD Gene:9958 USP25

dbSNP Gene:9958 USP25

ENSEMBL:ENSG00000135655 USP25

ENSEMBL_homo_sapiens_GENE:ENSG00000135655.16 USP25

HGNC:12613 USP25

KEGG Gene (Homo sapiens):9958 USP25

Monarch:9958 USP25

NCBI Gene:9958 USP25

OMIM:604731 USP25

UCSC:Q9Y4E8 USP25

Reference Transcript

Other Identifiers

11717777_a_at

11717778_at

11744582_a_at

11746454_a_at

11759626_at

11759627_at

16753299

209475_PM_at

209475_at

210681_PM_s_at

210681_s_at

231990_PM_at

231990_at

244028_PM_at

244028_at

3419148

3419149

3419163

3419164

3419168

3419175

3419179

3419181

3419185

3419186

3419187

3419191

3419195

3419200

3419201

3419202

3419204

3419205

3419206

3419207

3419208

3419210

3419211

3419212

3419214

3419218

3419220

3419221

3419222

3419223

3419229

3419231

3419233

3419234

3419236

3419238

34295_at

46464_at

78173_at

7956670

9958

A_14_P119912

A_14_P125673

A_14_P130232

A_23_P204269

A_23_P325802

A_32_P57057

GE53258

GE54806

GE647078

GE682910

GO:0002376

GO:0003824

GO:0004197

GO:0004843

GO:0005160

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006325

GO:0006508

GO:0007179

GO:0008233

GO:0008234

GO:0012501

GO:0016579

GO:0016604

GO:0016787

GO:0023052

GO:0030509

GO:0030512

GO:0035520

GO:0036211

GO:0042393

GO:0042802

GO:0043226

GO:0046332

GO:0061649

GO:0098542

GO:0101005

GO:0140096

GO:0140673

GO:1900246

GO:1902238

GO:1905035

GO:1990167

GO:1990380

HMNXSV003002894

HMNXSV003020417

HMNXSV003046602

Hs.103173.0.A1_3p_at

Hs.132288.0.S1_3p_at

ILMN_1665557

ILMN_1867588

PH_hs_0005728

PH_hs_0023884

TC12000555.hg

g5231132_3p_a_at

g5814096_3p_at

Participates

as a component of

as a member of

UCHL5/USP15 [cytosol] (Homo sapiens)

Inferred To

usp-4 [cytosol] (Caenorhabditis elegans)

USP15 [cytosol] (Bos taurus)

USP15 [cytosol] (Caenorhabditis elegans)

USP15 [cytosol] (Canis familiaris)

USP15 [cytosol] (Gallus gallus)

USP15 [cytosol] (Sus scrofa)

Homologues of USP15 [cytosol] (Caenorhabditis elegans)

Usp15 [cytosol] (Mus musculus)

Usp15 [cytosol] (Rattus norvegicus)

Ghost homologue of USP15 [cytosol] (Danio rerio)

Ghost homologue of USP15 [cytosol] (Drosophila melanogaster)

usp15 [cytosol] (Xenopus tropicalis)

usp-50 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_006304.1, NP_001239008.1, NP_001239007.1

OpenTargets

ENSG00000155313

IntEnz

3.4.19.12

HPA

ENSG00000135655-USP15

GeneCards

Q9Y4E8

Ensembl

ENSP00000280377, ENST00000312635, ENSG00000135655, ENST00000353364, ENST00000280377, ENSP00000309240, ENSP00000258123

PRO

Q9Y4E8

Pharos - Targets

Q9Y4E8

Orphanet

28190

HMDB Protein

HMDBP10137

PDB

6GHA, 3PPA, 6DJ9, 6CRN, 6CPM, 4A3P, 1W6V, 5JJW, 3T9L, 7R2G, 6ML1, 3LMN, 4A3O, 3PV1, 6GH9

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86TM6 SYVN1	1	SYVN1(1-617) [endoplasmic reticulum membrane] (R-HSA-535496)	0.668	8
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) CARD9 [plasma membrane] (R-HSA-5607662) p-T231-CARD9 [plasma membrane] (R-HSA-5607623)	0.666	4
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.556	3
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.556	3
UniProt:P60896 SEM1	2	SEM1 [nucleoplasm] (R-HSA-8866665) SEM1 [cytosol] (R-HSA-8866674)	0.527	2
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.508	2