Reactome | Binding and Uptake of Ligands by Scavenger Receptors

Binding and Uptake of Ligands by Scavenger Receptors

Stable Identifier

R-HSA-2173782

DOI

10.3180/REACT_160300.2

Type

Pathway

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, endocytic vesicle membrane

ReviewStatus

5/5

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Binding and Uptake of Ligands by Scavenger Receptors

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Scavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). Some scavenger receptors, such as the CD163-haptoglobin system, are specific for only one ligand. Others, such as the SCARA receptors (SR-A receptors) are less specific, binding several ligands which share a common property, such as polyanionic charges.
Brown and Goldstein originated the idea of receptors dedicated to scavenging aberrant molecules such as modified low density lipoprotein particles (Goldstein et al. 1979) and such receptors have been shown to participate in pathological processes such as atherosclerosis. Based on homology, scavenger receptors have been categorized into classes A-H (reviewed in Murphy et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
19388903	Scavenger receptors: role in innate immunity and microbial pathogenesis Areschoug, T, Gordon, S	Cell. Microbiol.	2009
19659436	Hemoglobin and heme scavenger receptors Nielsen, MJ, Møller, HJ, Moestrup, SK	Antioxid. Redox Signal.	2010
218198	Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition Goldstein, JL, Ho, YK, Basu, SK, Brown, MS	Proc. Natl. Acad. Sci. U.S.A.	1979
15904923	Biochemistry and cell biology of mammalian scavenger receptors Murphy, JE, Tedbury, PR, Homer-Vanniasinkam, S, Walker, JH, Ponnambalam, S	Atherosclerosis	2005
16511968	Hemoglobin and heme scavenging Ascenzi, P, Bocedi, A, Visca, P, Altruda, F, Tolosano, E, Beringhelli, T, Fasano, M	IUBMB Life	2005