Binding and Uptake of Ligands by Scavenger Receptors

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R-HSA-2173782
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Pathway
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Homo sapiens
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Scavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). Some scavenger receptors, such as the CD163-haptoglobin system, are specific for only one ligand. Others, such as the SCARA receptors (SR-A receptors) are less specific, binding several ligands which share a common property, such as polyanionic charges.
Brown and Goldstein originated the idea of receptors dedicated to scavenging aberrant molecules such as modified low density lipoprotein particles (Goldstein et al. 1979) and such receptors have been shown to participate in pathological processes such as atherosclerosis. Based on homology, scavenger receptors have been categorized into classes A-H (reviewed in Murphy et al. 2005).

Literature References
PubMed ID Title Journal Year
19659436 Hemoglobin and heme scavenger receptors

Nielsen, MJ, Møller, HJ, Moestrup, SK

Antioxid. Redox Signal. 2010
19388903 Scavenger receptors: role in innate immunity and microbial pathogenesis

Areschoug, T, Gordon, S

Cell. Microbiol. 2009
218198 Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

Goldstein, JL, Ho, YK, Basu, SK, Brown, MS

Proc. Natl. Acad. Sci. U.S.A. 1979
15904923 Biochemistry and cell biology of mammalian scavenger receptors

Murphy, JE, Tedbury, PR, Homer-Vanniasinkam, S, Walker, JH, Ponnambalam, S

Atherosclerosis 2005
16511968 Hemoglobin and heme scavenging

Ascenzi, P, Bocedi, A, Visca, P, Altruda, F, Tolosano, E, Beringhelli, T, Fasano, M

IUBMB Life 2005
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